Ansamycins having improved pharmacological and biological...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S231500, C514S252130, C514S308000, C514S339000, C514S359000, C514S361000, C514S378000, C514S403000, C514S422000, C514S444000, C514S471000, C540S456000

Reexamination Certificate

active

07465718

ABSTRACT:
Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and bioavailability. Some of the derivatives described are dimers. These and others described can include one or more solubilizing groups that have expected merit in rendering the overall compounds useful as drugs and prodrugs.

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