Ansamycin antibiotic

Details Ansamycin antibiotic Ansamycin antibiotic

1980-01-03

1981-01-27

Bond, Robert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424244, 435121, C07D49108

Patent

active

042474620

ABSTRACT:
A new subspecies of Streptomyces nigellus Prokop, designated Streptomyces nigellus Prokop subsp. africanus Huang subsp. nov. ATCC 31496, when propagated under aerobic conditions in aqueous nutrient media, produces a mixture of antibiotics. One of these antibiotics is the known macrolide antibiotic cirramycin A; the ansamycin antibiotic is an analogue of protostreptovaricin and the structure has been established as 21-hydroxy, 25-demethyl, 25-methylthioprotostreptovaricin I.

REFERENCES:
patent: 4031215 (1977-01-01), Sasaki et al.

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