Anorexigenic peptides

Details Anorexigenic peptides Anorexigenic peptides

1980-05-06

1982-05-04

Phillips, Delbert K.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

2601125TR, C08L 3700, C07C10352

Patent

active

043281346

ABSTRACT:
There are disclosed peptides of the formula A-B-C and pharmaceutically acceptable salts thereof, in which A is selected from the group consisting of L-pyroglutamyl, D-pyroglutamyl, and L-homo-pyroglutamyl; B is selected from the group consisting of L-histidyl, L-3'-methylhistidyl, D-histidyl, L-phenylalanyl, L-p-aminophenylalanyl, and L-.beta.-(pyrazolyl-1)alanyl; and C is selected from the group consisting of glycine and lower alkyl esters thereof, glycinamide and lower alkyl amides thereof, 2-amino-1-hydroxyethyl, D-alanine, L-.beta.-(2-thienyl)-alanine, and NHR.sup.1 in which R.sup.1 is lower alkyl, with the proviso that C may not be glycine or glycinamide when A is L-pyroglutamyl and B is L-histidyl.
The compounds have anorexigenic properties, inhibit excessive gastric and pancreatic secretion, and cause activation in the CNS. Methods for their preparation and use are also disclosed.

REFERENCES:
patent: 3749706 (1973-07-01), Geiger et al.
patent: 3876624 (1975-04-01), McGregor
patent: 3912705 (1975-10-01), Fujino et al.
patent: 3959248 (1976-05-01), Veber et al.
patent: 4066635 (1978-01-01), Gillessen et al.
Hofmann et al., Journal of Med. Chem. 1970, 13, 1099-1101.
Chang, et al., Journal of Med. Chem. 14, 1971, 484-487.

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