Anodynin, an endogenous opiate analgesic from human blood, and p

Details Anodynin, an endogenous opiate analgesic from human blood, and p Anodynin, an endogenous opiate analgesic from human blood, and p

1976-09-10

1978-02-14

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424177, A61K 3514, A61K 3700

Patent

active

040738850

ABSTRACT:
A method of recovering a hormone from human blood plasma which has morphine agonist properties which comprises heating said plasma, extracting into butanol to recover anodynin, and purifying said anodynin by centrifuging and ion exchange column separation. Anodynin has a molecular weight of about 600.

REFERENCES:
pert et al., Proc. Natl. Acad. Sci. U.S.A., 73 (1976).
Pert et al., Brain Research, 70:184-188 (1974).
Pert et al., Science, 179:1011-1014 (1733).
Pert, "The Opiats Receptor", Cell Membrane Receptors for Viruses, Antigens and Antibodies, Polypeptide Hormones, and Small Molecules, ed. by Beers and Bassett, Raven Press, New York, 1976 pp. 435-450.

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