Annexin derivatives suitable for pretargeting in therapy and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing

Reexamination Certificate

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C530S350000

Reexamination Certificate

active

08067357

ABSTRACT:
The present invention provides methods and compositions for the treatment and diagnosis of diseases such as neoplastic diseases, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and inflammatory diseases. The methods are based on the concept of pretargeting and include the administration of complexes comprising a recognizable compound A coupled to annexins, and the administration of complexes comprising of pharmaceutical or diagnostic compounds coupled to a compound B recognizing and binding to compound A to subjects. The compositions include annexins, annexin variants, that are not internalized by the target cells, derivatives thereof, and complexes thereof.

REFERENCES:
patent: 7511016 (2009-03-01), Reutelingsperger
patent: 2006/0024315 (2006-02-01), Schnitzer et al.
patent: WO 2006/003488 (2006-01-01), None
Clemen et al. 2001; Annexin VII; an astroglial protein exhibiting a Ca2+-dependent subcellular distribution. NeuroReport 12(6): 1139-1144.
Mira, et al., “Inhibition of Cytosolic Phospholipase A2 by Annex in V in Differentiated Permeabilized HL-60 Cells. Evidence of Crucial Importance of Domain I Type II Ca2+-Binding Site in the Mechanism of Inhibition,”Journal of Biological Chemistry,Apr. 18, 1997, vol. 272, No. 16, pp. 10474-10482.
Kenis, et al., “Cell Surface-Expressed Phosphatidylserine and Annexin A5 Open a Novel Portal of Cell Entry,”Journal of Biological Chemistry,Dec. 10, 2004, vol. 279, No. 50, pp. 52623-52629.
Huber, et al., “The Crystal and Molecular Structure of Human Annexin V, an Anticoagulant Protein that Binds to Calcium and Membranes,”Embo Journal,Dec. 1990, pp. 3867-3874.

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