Annelated indolo [3,2,-C]lactams

Details Annelated indolo [3,2,-C]lactams Annelated indolo [3,2,-C]lactams

1992-07-16

1993-06-29

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540579, 540581, 540582, 544 14, C07D51900

Patent

active

052236250

ABSTRACT:
The invention relates to a group of new annelated indolo [3,2-c] lactam derivatives of the formula ##STR1## having an antagonistic activity on 5-HT receptors. The compounds can be used for the treatment of symptoms which are caused by excessive stimulation of said receptors in the gastrointestinal system, the central nervous system, the cardiovascular system, the respiratory system, and for alleviating or preventing withdrawal symptoms which are induced by abuse of drugs.

REFERENCES:
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patent: 3914421 (1975-10-01), Rajagopalan
patent: 4939136 (1990-07-01), Haeck et al.
patent: 4985420 (1991-01-01), Hamminga et al.
patent: 4997831 (1991-03-01), Bays et al.
Uyeo et al., Chemical Abstracts, vol. 61, No. 10725a (1964).
Dahlgren et al., Chemical Abstracts, vol. 99, (1983), No. 70652g.

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