Annelated dihydropyridines and the use thereof for preparing pha

Details Annelated dihydropyridines and the use thereof for preparing pha Annelated dihydropyridines and the use thereof for preparing pha

1994-12-21

1997-08-26

Northington Davis, Zinna

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514291, 546147, 546148, 546149, 546 90, C07D40906, C07D21714, A61K 3147

Patent

active

056611579

ABSTRACT:
Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;
B denotes the group --0--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1-6)alkyl, phenyl or benzyl;
R.sup.3 denotes 2- or 3-thienyl, (C.sub.4-7)cycloalkyl, (C.sub.4-6)cycloalkyl(C.sub.1-5)alkyl or ##STR2## wherein R is (C.sub.1-4)alkyl, hydroxy, --N.sub.3, halogen (F, Cl, Br, I), CF.sub.3 or (C.sub.1-4)alkoxy,
u is 0, 1, 2 or 3, and
m, R.sup.2, R.sup.4, R.sup.7, R.sup.8 and R.sup.9 are as defined in the specification, as well as pharmaceutical preparations containing these compounds and the pharmaceutical use thereof.

REFERENCES:
patent: Re32519 (1987-10-01), Takacs et al.
patent: 4322418 (1982-03-01), Leosel et al.
patent: 4373104 (1983-02-01), Takacs et al.
patent: 4425349 (1984-01-01), Takacs et al.
Kansal et al, Indian Journal of Chemistry, Section B, vol. 20B, No. 10, pp. 885-890, Oct. 1981.
Arai et al, Chemical Abstracts vol. 68, No. 19, Abstract 94,351u, May 6, 1968.

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