Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2003-12-17
2008-12-16
Saoud, Christine J (Department: 1647)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S069100, C435S252300, C435S320100, C536S023500
Reexamination Certificate
active
07465581
ABSTRACT:
The methods and compositions of the invention are based on a method for measuring nociceptive responses in vertebrates, including humans and other mammals utilizing a newly discovered thermoreceptor belonging to the Transient Receptor Potential (TRP) family of non-selective cation channels that participates in thermosensation and pain. This receptor, designated ANKTMI, is associated with nociceptive pain, such as hyperalgesia. Accordingly, the invention provides isolated polypeptides and polynucleotides associated with nociception as well as methods for identifying or screening agents that modulate nociception.
REFERENCES:
Jaquemar et al. (1999). An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts. The Journal of Biological Chemistry. 274(11):7325-7333.
Bevan Stuart
Patapoutian Ardem
Story Gina M.
DLA Piper (LLP) US
Lockard Jon M
Novartis AG
Saoud Christine J
The Scripps Research Institute
LandOfFree
ANKTM1, a cold-activated TRP-like channel expressed in... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with ANKTM1, a cold-activated TRP-like channel expressed in..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and ANKTM1, a cold-activated TRP-like channel expressed in... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4026775