Anionic saccharides for extraction of anti-angiogenic protein fr

Details Anionic saccharides for extraction of anti-angiogenic protein fr Anionic saccharides for extraction of anti-angiogenic protein fr

1996-09-16

1998-12-01

Fonda, Kathleen K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 2, 424548, 424549, A61K 31715, A61K 3534

Patent

active

058439200

ABSTRACT:
Anti-angiogenic protein composition can be prepared simply and efficiently by contacting cartilage particles containing the protein together with an electrolyte solution and an oligosaccharide bearing a minimum number of anionic substituents per sugar unit, to extract the anti-angiogenic protein from the cartilage particles and to form a complex of the oligosaccharide and the protein. The resultant anti-angiogenic complex can be used for therapeutic treatment of various angiogenic and related diseases.

REFERENCES:
patent: 5019562 (1991-05-01), Folkman et al.
patent: 5183809 (1993-02-01), Weisz et al.
patent: 5262404 (1993-11-01), Weisz et al.
patent: 5268384 (1993-12-01), Galardy
patent: 5562535 (1996-10-01), Puppolo
patent: 5618925 (1997-04-01), Dupont et al.
Folkman et al, "Control of Angiogenesis with Synthetic Heparin Substitutes", Science 243, Mar. 17, 1989, pp. 1490-1493.
Lee et al, "Shark Cartilage Contains Inhibitors of Tumor Angiogenesis", Science, 221, Sep. 18, 1983, pp. 1185-1187.
Shing et al, "Affinity of Fibroblast Growth Factors for .beta.-Cyclodextrin Tetradecasulfate", Anal. Biochem. 185, 1990, pp. 108-111.
Mizobuchi et al, "Separation of Aromatic Amino Acids on .beta.-Cyclodextrin Polyurethane Resins", J. Chromatog. 208, 1981, pp. 35-40.
Otta et al, "Cyclodextrin-Cellulose Copolymers", Proceed. 4th Int. Symp. on Cyclodextrins, 1988, pp. 139-143.
Folkman et al, "Isolation of a Tumor Factor Responsible for Angiogenesis", J. Exp. Med. 133, 1971, pp. 275-288.
Snow et al, "Sulfated Glycosaminoglycans: A common Constituent of all Amyloids?", Lab. Invest. 56, No. 1, 1987, pp. 120-123.
Komiyama et al, "Immobilized .beta.-Cyclodextrin Catalyst for Selective Synthesis of 4-Hydroxybenzaldehyde", Polymer J., 18, No. 4, 1986, pp. 375-377.
Zsadon et al, "Cyclodextrin Polymers: Types and Specific Properties", Int. Symp. on Cyclodextrins, 1981, pp. 327-336.
Wiedenhof et al, "Properties of Cyclodextrins", Die Staerke, 21, 1969, pp. 119-122.
Grant et al, "Metachromatic Activity of Heparin and Heparin Fragments", Anal. Biochem. 137, 1984, pp. 25-32.
Scott et al, "Differential Staining of Acid Glycosaminoglycans by Alcian Blue in Salt Solutions", Histochemie, 5, pp. 221-232.

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