Animals, cells and methods for production of...

Details Animals, cells and methods for production of... Animals, cells and methods for production of...

2006-08-15

2006-08-15

Wehbe′, Anne Marie S. (Department: 1633)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S013000, C435S326000, C435S325000, C435S455000, C435S320100

Reexamination Certificate

active

07091396

ABSTRACT:
Genetically-modified mammals and immune cells are provided which are capable of producing or secreting detectably-labeled immunoglobulin molecules as a result of genetic modifications of at least one immunoglobulin gene in the genome thereof, such that a fusion polynucleotide encoding a detectable protein or peptide and an immunoglobulin component molecule is present.

REFERENCES:
patent: 5202238 (1993-04-01), Fell et al.
patent: 6570061 (2003-05-01), Rajewsky et al.
Casey et al. (2000) Prot. Engineer., vol. 13 (6), 445-452.
Casey, Joanne L. et al. Protein Engineering vol. 13 (No. 6); pp. 445-452 (2000) “Green Fluorescent Antibodies: novelin vitrotools”.

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