Animal with the mass expression of human gene and test...

Details Animal with the mass expression of human gene and test... Animal with the mass expression of human gene and test...

2007-04-10

2007-04-10

Kaushal, Sumesh (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S003000

Reexamination Certificate

active

10089883

ABSTRACT:
The present application provides a human gene over-expressing animal, which is a non-human animal carrying a human hematopoietic prostaglandin D2synthase gene in its somatic cell chromosome and expressing a large amount of human prostaglandin D2synthase, wherein the animal is one obtained through ontogenesis of a totipotency cell of a non-human animal or offspring of the obtained animal, and the totipotency cell is introduced with said synthase gene. The present application also provides a method of using the transgenic animal for testing in vivo activity of a candidate for anti-allergy medicines, sleep-controlling substances and candidates for anti-obesity.

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