Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1996-09-13
1998-12-15
Ziska, Suzanne E.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
4351723, 4353201, 536 231, 536 235, 424 91, 800DIG1, 800DIG4, C12N 1500, A61K 4900, C07H 2104
Patent
active
058500022
ABSTRACT:
Genetically engineered animals are described that have lost the expression of a homeobox gene and are missing an organ whose development is regulated by that homeobox gene. Such animals are models for organogenesis and can be used in methods for screening for compounds and gene therapies that restore the function of the missing organ. Other genetically engineered animals are described which express a homeobox gene in cells not normally expressing the gene and exhibit a developmental and/or pathologic condition in those cells. Such animals are models for gain of homeobox function and can be used in methods to screen for compounds and gene therapies that affect the developmental and/or pathologic condition due to the gain of homeobox gene expression.
REFERENCES:
patent: 4868116 (1989-09-01), Morgan et al.
patent: 4980286 (1990-12-01), Morgan et al.
Connelly et al Exp Cell Res 183: 257, 1989.
Zumar et al Nature 338: 150, 1989.
Roberts et al Blood 82(10): Abstract #332, p. 86a, 1993.
Hatano et al Blood, 1992, Abstr. #1412, p. 355a 34.sup.th Annual Meeting.
Balling, R. et al., "Cranofacial Abnormalities Induced by Ectopic Expression of the Homeobox Gene Hox-1,1 in Transgenic Mice," Cell 58:367-378 (1989).
Begley, C. G., et al., "The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif," Proc. Natl. Acad. Sci. USA 86:10128-10132 (1989).
Carter, Mouse News Lett. 11:16 (1954)*.
Chaffin, K. E. et al., "Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferse," EMBO J. 9:3821-3829 (1990).
Chisaka, O. et al., "Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5," Nature 350:473-479 (1991).
Chisaka, O. et al., "Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disrupton of the mouse homeobox gene Hox-1.6," Nature 355:516-520 (1992).
Conley, M. E. et al., "The spectrum of the DiGeorge syndrome," J. Pediatrics 94:883-890 (1979).
Crist, W. M., et al., "Acute Lymphoid Leukemia," Clinical Pediatric Oncology (Editors Fernbach, D.J., et al., pp. 305-336, Mosby Year Book, St. Louis, 1991).
Dear, J. et al., "The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct famly of homeobox genes," Proc. Natl. Acad. Sci. USA 90:4431-4435 (1993).
Dodd, et al., "Spatial Regulation of Axonal Glycoprotein Expression on Subsets of Embryonic Spinal Neurons," Neurons 1:105-116 (1988).
Dube, et al., "A Novel Human Homeobox Gene Lies at the Chromosome 10 Breakpoint in Lymphoid Neoplasias With Chromosomal Translocation t(10;14)," Blood 78:2996-3001 (1991).
Duboule, D., et al., "The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes," EMBO J. 8:1497-1505 (1989).
Feinberg, et al., "A Technique for Radiolabeling DNA Restriction Endonuclease Fragments to High Specific Activity," Anal. Biochem. 132:6-13 (1983).
Gaunt, S.J. et al., Development, 107: 131-141 (1989).
Gehring, "Homeo Boxes in the Study of Development," Science 236:1245-1252 (1987).
Gossler, et al., "Transgenesis by means of blastocyst-derived embryonic stem cell lines," Proc. Natl. Acad. Sci. USA 83:9065-9069 (1986).
Graham, A., et al., "The Murine and Drosophila Homeobox Gene Complexes Have Common Features of Organization and Expression," Cell 57:367-378 (1989).
Green, M.C., "A Defect of the Splanchnic Mesoderm Caused by the Mutant Gene Dominant Hemimelia in the Mouse," Dev. Biol. 15:62-89 (1967).
Greenburg, F., "What defines DiGeorge anomaly?" J. Pediatrics, 11:412-413 (1989).
Guthrie, S., et al., "Neuroectodermal autonomy of Hox-2.9 expression revealed by rhombomere transpositions," Nature 356:157-159 (1992).
Hatano, Masahiko, et al., "Deregulation of a Homeobox Gene, HOX11, by the t(10;141) in T Cell Leukemia," Science 253:79-82 (1991).
Hunt, P., et al., "Deciphering the Hox Code: Clues to Patterning Branchial Regions of the Head," Cell 66:1075-1078 (1991).
Kennedy, et al., "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24," Proc. Natl. Acad. Sci. USA 88:8900-8904 (1991).
Kessel, M., et al., "Homeotic Transformations of Murine Vertebrae and Concomitant Alteration of Hox Codes Induced by Retinoic Acid," Cell 67:89-104 (1991).
Keynes, R., and A. Lumsden, "Segmentation and the Origin of Regional Diversity in the Vertebrate Central Nervous System," Neuron 2:1-9 (1990).
Korsmeyer, S. J., "Chromosomal Translocations in Lymphoid Malignancies Reveal Novel Proto-Oncogenes," Annu. Rev. Immunol. 10:785-807 (1992).
Kreidberg, J.A., et al., "WT-1 Is Required for Early Kidney Development," Cell 74:679-691 (1993).
LeMouellic, H., et al., "Homeosis in the Mouse Induced by a Null Mutation in the Hox-3.1 Gene," Cell 69:251-264 (1992).
Lu, M., et al., "The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein," EMBO J. 10:2905-2910 (1991).
Lufkin, T., et al., "Disruption of the Hox-1.6 Homeobox Gene Results in Defects in a Region Corresponding to Its Rostral Domain of Expression," Cell 66:1105-1119 (1991).
Manseau and Schupbach, "The egg came firs, of course|" Trends Genet. 5:400-405 (1980).
Mansour, Suzanne, L., et al., "Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes," Nature 336:348-352 (1988).
Marsh, J. Lawrence, et al., "The plC plasmid and phage vectors with versatile cloning sites for recombinant selection by insertional inactivation," Gene 32:481-485 (1984).
McGinnis, W., et al., "Homeobox Genes and Axial Patterning," Cell 68:283-302 (1992).
McGuire, Elizabeth A., et al., "Thymic Overexpression of Ttg-1 in Transgenic Mice Results in T-Cell Acute Lymphoblastic Leukemia/Lymphoma," Molec. Cell. Biol. 12:4186-4196 (1992).
McGuire, et al., "The t(11;14)(p15;g11) in a T-Cell Acute Lymphoblastic Leukemia Cell Line Activates Multiple Transcripts, Including Ttg-1, a Gene Encoding a Potential Zinc Finger Protein," Molec. Cell. Biol. 9:2124-2132 (1989).
McKnight, Steven, "the nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene," Nucleic Acids Res. 8;5949-5965 (1980).
Mulligan, "The Basic Science of Gene Therapy," Science 260:926-932 (1993).
Niehrs, C., et al., "Vertebrate axis formation," Curr. Opin. Genet. Dev. 2:550-555 (1990).
Noltenius, H., Human Oncology: Pathology and Clinical Characteristics, vol. 8, pp. 1238-1242 (Editors, Noltenius, H., Urban & Schwarzenberg, Baltimore, 1988).
Rabbits, T. H., "Translocations, Master Genes, and Differences between the Origins of Acute and Chronic Leukemias," Cell 67:641-644 (1991).
Raju, R., et al., Characterization and developmental expression of Tlx-1, the murine homolog of HOX11, Mechanisms of Development 44:51-64 (1993).
Ramirez-Solis, R., et al., "Hoxb-4 (Hox-2.6), Mutant Mice Show Homeotic Transformation of a Cervical Vertebra and Defects in the Closure of the Sternal Rudiments," Cell 73:279-294 (1993).
Roberts, Charles Willard Mortimer, "Identification, Characterization, and Gene Ablation of the Oncogene Homeobox SPX (HOX11)," a dissertation presented to the Graduate School of Arts and Sciences of Washington University (May 1995).
Roberts, Charles, W.M., "Hox11 controls the genesis of the spleen," Nature 368:747-749 (1994).
Sambrook, et al., Molecular Cloning: A Laboratory Manual, Second Edition, pp. 2.33, 9.31-9.62, Cold Spring Harbor Laboratory Press (1989).
Sanchez-Herrero, et al., "Genetic organization of Drosophila bithorax complex," Nature 313:108-113 (1985).
Scott, M.P. et et al., "The structure and function of the homeodomain," Biochim. Biophys. Acta 989:25-48 (1989).
Stern, C.D., "Vertebrae gastrulation," Curr. Opin. Genet. Dev. 2:556-561 (1990).
Swat, W. et al., "Detection of apoptosis of immature CD4.sup.+ 8.sup.+ thymocytes by flow cytometry," J. Immunol. Meth. 137:79-87 (1991).
Wakimoto, et al., "Analysis of Larval Segmentation in Lethal Genotypes Associated with the Antennapedia Gene Complex in Drosophila melanogaster," De
Washington University
Ziska Suzanne E.
LandOfFree
Animal models for loss and gain of Hox11 function does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Animal models for loss and gain of Hox11 function, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Animal models for loss and gain of Hox11 function will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1460071