Animal model with disrupted FGF-9 gene

Details Animal model with disrupted FGF-9 gene Animal model with disrupted FGF-9 gene

1999-02-24

2000-10-24

Chambers, Jasemine

Bleaching and dyeing; fluid treatment and chemical modification

Treatment of hides, skins, feathers and animal tissues

Tanning

8 21, A01K 67027, C12N 1500

Patent

active

061360406

ABSTRACT:
A unique animal model is disclosed which is useful for studying the role of FGF-9 activity in cardiovascular diseases. To provide this animal model, the FGF-9 gene is disrupted in mice, that is, null mutation in the mouse FGF-9 gene is engineered. This knockout mouse was produced by deleting the sequences immediately downstream of the initiation methionine in exon 1. Analysis of the FGF-9 null embryos demonstrates perinatal lethality with apparent pathology in lung and cardiac tissue.

REFERENCES:
patent: 5891655 (1999-04-01), Ornitz
Seamark RF. Reprod. Fertil. Dev. 6:653-657, 1994.
Meredith RW et al. J. Mol. Med. 75:208-216, 1997.
Mullins LJ and Mullins JJ. J. Clin. Invest.97:1557-1560, 1996.
Ornitz, et al.; J. Biol. Chem., vol. 271, No. 25, pp. 15292-15297 (1996).
Naski, et al.; Nature Genetics, vol. 13 pp. 233-237 (1996).
Santos-Ocampo et al.; J. Biol. Chem. vol. 271, No. 3 pp. 1726-1731 (1996).
Colvin, et al.; Nature Genetics, vol. 12, pp. 390-397 (1996).

Affiliated with

Also associated with

Rating

Animal model with disrupted FGF-9 gene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Animal model with disrupted FGF-9 gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Animal model with disrupted FGF-9 gene will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1959311