Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1993-08-06
1997-09-02
Ziska, Suzanne E.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
424 937, 800DIG15, C12N 1500, A01N 6300
Patent
active
056634811
ABSTRACT:
The present invention relates to a non-human chimeric mammal having characteristics of a functional human immune system and having functional human lymphocytes reconstituted in the mammal's lymphopoietic tissue, particularly the spleen. The invention also relates to a method of preparing a non-human chimeric mammal, having characteristics of a functional human immune system, by engraftment of human peripheral blood leukocytes into an immunocompromised mammal. Use of the chimeric mammal as a model of the human immune system is described.
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Gallinger Steven
Hozumi Nobumichi
Roder John C.
Sandhu Jasbir S.
Shpitz Baruch
Mount Sinai Hospital Corporation
Ziska Suzanne E.
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