Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Patent
1997-09-12
1998-11-10
Campell, Bruce R.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
119174, 800DIG4, A61K 4900, A01K 2900
Patent
active
058339450
ABSTRACT:
The present invention provides a phenotypically stable altered animal which exhibits unprovoked rage reaction indicative of high emotionality, stereotyped behavior and is useful as a model of psychotic behavior. The animals of this invention (F.sub.2) were obtained by inbreeding mature offspring (F.sub.1) of rats whose mothers received high tryptophan diets during their third trimester of gestation. There is also an increased body weight which evidences physical alteration. The present invention also relates to the preparation and use of animal models for the study of psychosis, pathological psychotic behavior in humans and the effects of tryptophan in successive generations. The prenatal effects of tryptophan on later generations can also be used to increase the body weight of experimental animals and livestock.
REFERENCES:
patent: 4736866 (1988-04-01), Leder et al.
R Arevalo et al (1991) Life Sci 49:53-66 (Abstract).
L Allikmets (1975) Sint. Izuch. Fiziol. Akt. Veshchestv, Tezisy Dolcl. Mezhvuz Nauchn. Konf. Uchastieun, 1975, 7-11 (Abstract).
KM Kantak et al (1980) Pharmacol. Biochem Behav 12:173-9.
MD Tricklebank et al (1978) Pharmacol. Biochem. Behav 9:181-189.
Archer, J., "Tests for Emotionality in Rats and Mice: A Review", Anim. Behav. 21:205-235 (1973).
Bogdanski, D.F. et al., "Pharmacological Studies with the Serotonin Precursor, 5-Hydroxytryptophan", J. Pharmacol Exper. Therapeut. 122:182-194 (1958).
Broadhurst, P.L., "Psychogenetics of Emotionality in the Rat", N.Y. Acad. Sci. Ann. 159:806-824 (1969).
Broadhurst, P.L., "Maternal Effects in the Inheritance of Behavior", Animal Behav. IX, 3-4:131-141 (1960).
Broadhurst, P.L., "The Maudsley Reactive and Nonreactive Strains of Rats: A Survey", Behavior Genet. 5:299-318 (1975).
Falconer, D.S., "Selection of Mice for Growth on High and Low Planes of Nutrition", Genetic Res. 1:91-113 (1960).
Fog, R., "Rage Reactons Produced in Rats By a Combnation of Thymo-Leptics and Monoamine Oxidase Inhibitors", Pharmacol. Res. Commun. 1:76-83 (1969).
Fuller, J.L. et al,. Foundation of Behavioral Genetics (The C.V. Mosbly Co., St. Louis, MO) pp. 17-20, 32-39, 50-73, 77-93, 99-111, 155-179, 475-515 (1978).
Furchtgott, E. et al., "Activity and Emotionality in Pre-and Neonatally X-Irradiated Rats", J. Comp. Physiol. Psychol. 51:541-545 (1958).
Gottlieb, J.S. et al., "The Effect of Antimetabolics on Embryonic Development", JMSMS 57:364-366 (1958).
Hall, C.S., "The Inheritance of Emotionality", Sigma XI Quartlery 26:16-27, 37 (1938).
Hall, C.S., "Defecation and Urination as Measures of Individual Differences in Emotionality", J. Comp. Psychol. 18:385-403 (1934).
Hockman, C.H., J. Comp. Physiol. Psychol. 54(6):679-684 (1961).
Ladias, J.A. et al., "A New Apolipoprotein B-100 Variant in a Family With Premature Atherosclerosis and Hyerapobetalipoproteinemia", JAMA 262:1980-188 (1989).
Lewis, A.J. et al., "Determination of the Optimum Dietary Proportions of Lysine and Tryptophan For Growing Rats Based on Growth, Food Intake, and Plasma Metabolites", J. Nutrition 107:1361-1368 (1977).
Mayeno, A.N. et al., "Characterization of `Peack E,` a Novel Amino Acid Associated with Eosinophilia -- Myalgia Syndrome", Science 250:1707-1708 (1990).
MMWR, "Analysis of L-Tryptophan For The Etiology of Eosinophilia -- Myalgia Syndrome" 39:587-591 (1990).
Pare, W.P. "Relationship of Varous Behaviors in the Open-field Test of Emotionality", Psycholol. Reports 14:19-22 (1964).
Pike, R.L., "congential Cataract in Albino Rats Fed Defferent Amounts of Tryptophan and Niacin", J. of Nutrition 44:191-204 (1951).
Pond, W.G. et al., "Effects of The .alpha.-Keto Analogue ot Tryptophans and The Level of the Corresponding Amno Acids on Growth of Rats", J. Nutrition 83:85-93 (1964).
Randrup, A. et al., "Dopa and Other Naturally Occurring Substances as Causes of Stereoptypy and Rage in Rats", Acta Psychiat. Scand Suppl. 191(42):193-199 (1966).
Reuter, "Better Diet May Help Asian Kids Grow Bigger in U.S.," The Detroit News, Feb. 19,1992.
Sakimoto, K., "The Cause Of The Eosinophilia -- Myalgia Syndrome Associated With Tryptophan Use" New Engl. J. Med. 323:992-993 (1990).
Sakuma, M. Soc. Neuroscience, "A Study of the Adverse Effects of 5-HT Precursor-Treatments Related to EMS", Abstract (1992).
Sakuma, M. et al., "Effects of Prenatal Tryptophan Diets on Behavior in Mature Rats", Federation Proceedings, Abstract, vol. 43:1974 (1984).
Sudak, H.S. et al., "Behavioral -- Neurochemical Correlation in Reactive and Nonreactive Strains of Rats", Science 146:418-420 (1964).
Thompson, W.R. "Influence Of Prenatal Maternal Anxiety On Emotionality In Young Rats" Science 125:698-699 (1957).
Vincent, N.M. "The Effects Of Prenatal Alcoholism Upon Motivation, Emotionality, and Learning In The Rat" Amer. Psychologist 13:401 (1958).
Warkany, J. et al., "Congenital Malformations Induced in Rats by Maternal Nutritional Defiency", Society for Experimental biology and Medicine, Abstract, 54:92-94, 14317P (1943).
Warkany, J. et al., "Congenital Malformations Induced in Rats by Maternal Riboflavin Defiency: Dentofacial Changes", J. Amer. Dental Assoc. 51:139-154 (1955).
Werboff, J. et al., "Behavioral Effects of Prenatal Drug Administration in the White Rat" Pediatrics 27:318-324 (1961).
Werboff, J. et al., "Postnatal Effect of Antidepressent Drugs Administered During Gestation", Exp. Neur. 3:542-555 (1961).
Curtis, P.B. et al., "The Nutritive Value of Certain Animal Protein Concentrates", J. of Nutr. 5:503-517 (1932).
Fernstrom, J.D. et al., "Effects of Skim Milk, Whole Milk and Light Cream on Serum Tryptophan Binding and Brain Trytophan Concentrates in Rats", J. of Nutr. 105:1359-1362 (1975).
Khorasanizadeh, S. et al., "Folding and Stability of a Tryptophan-Containing Mutant of Ubiquitin", Biochem. 32:7054-7063 (1993).
Ladokhin, A.S. et al., "Flourescence Study of a Mutant Cytochrome b.sub.5 with a Single Tryptophan in the Membrane-Binding Domain" Biochem. 30:10200-10206 (1991).
Lauder and Krebs, "Serotonin as a Differentiation Signal in Early Neurogenesis", Dev. Neurosci. 1:15-30 (1978).
"Nerve Cells and Electric Properties of Cell Membranes", Molecular Cell Biology (Scientific American Biology) pp. 786-788, 798-799 (1990).
"Serotonin -- New Vistas -- Biochemistry and Behaviorial and Clinical Studies", Advances in Biochemical Psychopharmocology (Raven Press, New York) pp. 133-142 (1974).
Yehuda, S. et al., "Increased Serotonin Level Via Augmented Tryptophan Diet and Its Effects on Escape Learning", Inter. J. Neuroscience 15:193-196 (1981).
I Lieblich et al (1980) Brain Research 185:253-264.
DV Coscina et al (1973) Pharm Biochem Behav 1:1-6.
LandOfFree
Animal model of pathological behavior does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Animal model of pathological behavior, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Animal model of pathological behavior will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1513705