Animal model of human hematopoietic tumor

Details Animal model of human hematopoietic tumor Animal model of human hematopoietic tumor

2007-08-21

2007-08-21

Wilson, Michael (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Method of making a transgenic nonhuman animal

C800S003000, C800S008000, C435S325000

Reexamination Certificate

active

10533796

ABSTRACT:
Production and utilization of model mouse, in which human hematopoietic tumor cells can be grown, expressing symptom of human hematopoietic tumor, and can be used in the screening of anticancer drugs for human hematopoietic tumor.The invention provides a new method to produce model mouse for human hematopoietic tumor, including engraftment of human hematopoietic tumor cells into NOG (NOD/Shi-scid, IL-2Rγ KO) mice.

REFERENCES:
patent: 2003/0182671 (2003-09-01), Ito et al.
patent: WO 02/43477 (2002-06-01), None
Blase et al. (1995) Int. J. Cancer 60: 860-865.
Mitsuyoshi Urashima, et al., “The Development of a Model for the Homing of Multiple Myeloma Cells to Human Bone Marrow”, BLOOD, American Society of Hematology, vol. 90, No. 2 Jul. 15, 1997; pp. 754-765.
Yoshi Miyakawa, et al., “Establishment of Human Multiple Myeloma Model Using Newly Developed Immunodeficienent NOD/SCID./IL-2Rγ-/- (NOG) Mice”, Abstract #2366, Poster Board #-Session 650-II, American Society of Hematology, vol. 100, No. 11 Nov. 16, 2002; pp. 601a.

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