Animal model for hyperpigmentation

Details Animal model for hyperpigmentation Animal model for hyperpigmentation

2011-07-05

2011-07-05

Li, Q. Janice (Department: 1633)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

The nonhuman animal is a model for human disease

C800S008000

Reexamination Certificate

active

07973211

ABSTRACT:
An animal model for hyperpigmentations in which the formation of hyperpigmentations in human skin is faithfully simulated is provided. An animal model for hyperpigmentations, wherein a black person's skin is grafted onto a non-human animal, is provided.

REFERENCES:
patent: 5719126 (1998-02-01), Nordlund et al.
patent: 7285570 (2007-10-01), Robinson et al.
patent: 2006/0058252 (2006-03-01), Clawson et al.
patent: 2008/0263686 (2008-10-01), Hachiya et al.
Maeda et al. J Dermatol Sci 1997;14:199-206.
Game et al, Wien Klin Wochenschr 2001;113:832-8.
Platt et al. Nat Biotech Mar. 2002;20(3)231-2.
Richardson et al. J Invest Dermol 2006;126:79-84.
Dahlen, DD et al., “Soluble Kit receptor blocks stem cell factor bioactivity in vitro,” Leuk Res, 25(5): 413-21 (May 2001), Elsevier Science Ltd., Oxford, UK.
Hattori, H. et al., “The epidermal stem cell factor is over-expressed in lentigo senilis: implication for the mechanism of hyperpigmentation,” J Invest Dermatol, 122(5): 1256-65 (May 2004), Blackwell Publishing Inc., MA.
Kadono, S et al., “The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilis,” J Invest Dermatol 116(4): 571-7 (Apr. 2001), Blackwell Publishing Inc., MA.
Motokawa, T et al., “Messenger RNA levels of melanogenesis-associated genes inLentigo senilislesions,” J. Dermatol Sci, 37(2): 120-3 (Feb. 2005), Elsevier Ireland Ltd., Shannon, Ireland.
Hachiya, A., et al., “The Paracrine Role of Stem Cell Factor/ c-kit Signaling in the Activation of human Melanocytes in Ultraviolet-B-Induced Pigmentation,”J. Invest. Dermatol. 116:578-586, Nature Publishing Group (2001).
Imokawa, G., et al., “Differential Analysis of Experimental Hypermelanosis Induced by UVB, PUVA, and Allergic Contact Dermatitis Using a Brownish Guinea Pig Model,”Arch. Dermatol. Res. 278:352-362, Springer Verlag (1986).
Kawaguchi, Y., et al., “Kit+Melanocytes Seem to Contribute to Melanocyte Proliferation After UV Exposure as Precursor Cells,”J. Invest. Dermatol. 116:920-925, Nature Publishing Group (2001).
Seiberg, M., “Keratinocyte-Melanocyte Interactions During Melanosome Transfer,”Pigment Cell Res. 14:236-242, Munksgaard International Publishers (2001).
Welsh, B.M., et al., “Topical All-transRetinoic Acid Augments Ultraviolet Radiation-Induced Increases in Activated Melanocyte Numbers in Mice,”J. Invest. Dermatol. 112:271-278, Nature Publishing Group (1999).
U.S. Appl. No. 11/785,549, inventors Hachiya, A., et al., filed Apr. 18, 2007 (Not Yet Published).
Broome Powell, M., et al., “Hyperpigmentation and Melanocytic Hyperplasia in Transgenic Mice Expressing the Human T24 Ha-rasGene Regulated by a Mouse Tyrosinase Promoter,”Molec. Carcinogenesis 12:82-90, Wiley-Liss, Inc. (1995).
Hachiya, A., et al., “An In Vivo Mouse Model of Human Skin Substitute Containing Spontaneously Sorted Melanocytes Demonstrates Physiological Changes after UVB Irradition,”J. Invest. Dermatol. 125:364-372, The Society for Investigative Dermatology, Inc. (2005).
Yoshida, Y., et al., “Functional analysis of keratinocytes in skin color using a human skin substitute model composed of cells derived from different skin pigmentation types,”FASEB J. 21:2829-2839, Federation of American Societies for Experimental Biology (Sep. 2007).
Extended European Search Report for corresponding European Application No. 08007510.4, mailed Sep. 9, 2008, European Patent Office, The Hague.

Affiliated with

Also associated with

Rating

Animal model for hyperpigmentation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Animal model for hyperpigmentation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Animal model for hyperpigmentation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2726438