Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1995-05-16
1998-12-15
Chambers, Jasemine C.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
435237, 435239, 4353201, 435 691, 435 693, 4351723, 435 912, 4352402, 424 92, C12N 1586, C12N 1549, C12N 708, C12N 702
Patent
active
058499946
ABSTRACT:
HIV-1 does not cause disease in any non-human species. Thus, there is no animal model system to evaluate the efficacy of strategies aimed at preventing or ameliorating disease caused by this virus. The instant invention provides an animal model for HIV-1 induced disease, virus for generating such model animals, and methods for generating pathogenic SHIV.
REFERENCES:
Sakuragi, S. et al. (1992) "Infection of macaque monkeys with a chimeric human and simian immunodeficiency virus" Journal of General Virology 73:2983-2987.
Li, J. et al. (1992) "Infection of Cynomolgus Monkeys with a Chimeric HIV-1/SIV.sub.mac Virus That Expresses the HIV-1 Envelope Glycoproteins" Journal of Acquired Immune Deficiency Syndromes 5:639-646.
Shibata, R. and Adachi, A. (1992) "SIV/HIV Recombinants and Their Use in Studying Biological Properties" AIDS Research and Human Retrviruses 8(3):403-409.
Sharma, D.P. et al. (1992) "Derivation of Neurotropic Simian Immunodeficiency Virus from Exclusively Lymphocytetropic Parental Virus: Pathogenesis of Infection in Macaques" Journal of Virology 66(6):3550-3556.
Barnett, S.W. et al. (1994) "An AIDS-Like Condition Induced in Baboons by HIV-2" Science 266:642-646.
North, T.W. and LaCasse, R.A. (1995) "Testing anti-HIV drugs in the FIV model" Nature Medicine 1(5):410-411.
Desrosiers, R.C. (1990) "The Simian Immunodeficiency Viruses" Annual Review of Immunology 8:557-578.
Lewis and Johnson, 1995, "Developing animal models for AIDS research--progress and problems" Trends in Biotechnology 13:142-150.
Levy, J. A., Journal of Medical Primatology, vol. 25, pp. 163-174, 1996.
Chambers Jasemine C.
Schmuck Jill D.
University of Kansas Medical Center
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