Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1994-05-13
1998-12-15
Stanton, Brian R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
4351723, C12N 506, C12N 1509
Patent
active
058499873
ABSTRACT:
Chimeric mouse and rat models useful as models for human hepatitis virus (HV) infection are disclosed. These chimeras are made by substantially destroying the hematopoietic cells of a host mouse or rat and then transplanting into the resultant animal hematopoietic cells from SCID mice. The resultant chimera is then used as a host for transplantation of xenogeneic liver tissue, including liver tissue from humans. The liver tissue may be infected with HV either prior to or after transplantation.
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Stanton Brian R.
Yeda Research and Development Co. Ltd.
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