Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1994-07-11
1997-04-29
Campell, Bruce R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
800DIG1, 424 92, 435 721, 4351723, 435354, 935 59, C12N 500, A61K 4900, G01N 33567
Patent
active
056251246
ABSTRACT:
Transgenic non-human animals are described which serve as a model for H. pylori infection of epithelial cells of the stomach and small intestine. The gut epithelial cells of the transgenic animals express one or more surface carbohydrate antigens which act as receptors for the bacterium H. pylori, a known causative agent of acid peptic disease, such as gastritis, stomach ulcers, duodenal ulcers, and strongly correlated with the development of gastric neoplasia. Methods for making and using the transgenic animals are also disclosed. The transgenic animals can be used to screen for compounds and conditions which block binding of H. pylori to the gut epithelium and/or ameliorate the H. pylori-associated pathogenesis of acid peptic disease and gastric adenocarcinoma.
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Falk Per
Gordon Jeffrey I.
Campell Bruce R.
Washington University
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