Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1993-05-03
2000-01-25
Stanton, Brian R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
424 931, 424 937, 424 9371, 4351723, A01N 6300, C12N 1500
Patent
active
06018096&
ABSTRACT:
A chimeric, non-human, genetically-immunocompetent mammal is disclosed. The hematopoietic system of the mammal has human passaged bone marrow stromal cells and human hematopoietic stem cells obtained from a CD34.sup.+ -enriched bone marrow fraction, and also contains transplanted syngeneic non-lymphoid spleen colony cells. The mammal may be a mouse, a rat, a rabbit, a cat, a dog, a pig, a sheep or a non-human primate. The mammal can be produced by providing a non-human, genetically-immunocompetent mammal in which its immunologic genotype comports with the norm for the species of the mammal, exposing the mammal to a level of x- or gamma-radiation that is sufficient to destroy substantially all bone marrow in the mammal to render the mammal phenotypically immunodeficient, then transplanting into the mammal syngeneic non-lymphoid spleen colony cells and human passaged bone marrow stromal cells, and transplanting into the mammal human hematopoietic stem cells obtained from a CD34.sup.+ -enriched bone marrow fraction. Human hematopoietic cells may be obtained from the chimeric, non-human mammal.
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Keating Armand
Wu Dong-dong
Stanton Brian R.
Surrogen, Inc.
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