Animal model for allergic disorders

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – The nonhuman animal is a model for human disease

Reexamination Certificate

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C800S008000, C424S275100, C424S184100, C424S093100, C514S002600, C530S350000, C530S300000

Reexamination Certificate

active

07094946

ABSTRACT:
An animal suitable as a model for an allergic disorder, wherein the animal is an immuno-modulated animal which has been sensitized with an antigen under a specific pathogen free environment such that when the animal displays allergy symptoms caused by the antigen.

REFERENCES:
Yasue et. al.; Inhibition of Airway Inflammation in rDer f 2-Sensitized Mice by Oral Administration of Recombinant Der f 2. 1997. Cellular Immunology 181: 30-37.
Gad. S. C. 1994. “The mouse ear swelling test (MEST) in the 1990s”. Toxicology, vol. 93 (1), 33-46.
Tsutomu Koizumi et al . . . , “The Role of Immunity on the Development of the Dermatitis in NC Mice”, Exp. Anim. vol., 35, No. 2, pp. 159-163, 1986.
Hiroshi Matsuda et al., “Development of Atopic Dermatitis-Like Skin Lesion with IgE Hyperproduction in NC/Nga Mice”, International Immunology, vol. 9, No. 3, pp. 461-466, 1996.
Jun Hiroi et al., “Effect of Tacrolimus Hydrate (FK506) Ointment on Spontaneous Dermatitis in NC/Nga Mice”, Jpn. J. Pharmacol., vol. 76, pp. 175-183, 1998.
Eishin Morita et al., “Fur Mites Induce Dermatitis Associated with IgE Hyperproduction in an Inbred Strain of Mice, NC/Kuj”, Journal of Dermatological Science, vol. 19, pp. 37-43, 1999.
“Guide for the Care and Use of Laboratory Animals”, Institute of Laboratory Animal Resources Commission on Life Sciences National Research Council, National Academy Press, Washington, D.C. 1996, pp. 75-76.

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