Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1981-06-03
1982-10-26
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424304, A61K 3118, A61K 31275
Patent
active
043561918
ABSTRACT:
A process for increased productivity in healthy animals comprising the administration of a compound of the formula ##STR1## or a pharmacologically acceptable acid addition salt thereof wherein R.sub.1 is chloro, bromo, or alkyl of 1 through 4 carbon atoms; R.sub.2 is hydrogen, chloro, bromo, or alkyl of 1 through 4 carbon atoms; R.sub.3 is (1) alkyl of 1 through 8 carbon atoms, (2) cycloalkyl of 5 through 8 carbon atoms, (3) phenalky wherein alkyl is 1 or 2 methylene units in length, or (4) phenyl where the phenyl is unsubstituted or substituted with 1 through 3 substituents selected from the group consisting of methyl, chloro, bromo, nitro, trifluoromethyl, alkoxy of 1 or 2 carbon atoms, and cyano, and R.sub.4 is (1) alkyl of 1 through 4 carbon atoms, (2) phenalkyl wherein alkyl is 1 or 2 methylene units in length and where the phenyl is unsubstituted or substituted with 1 through 3 substituents selected from the group consisting of methyl, chloro, bromo, nito, trifluoromethyl, alkoxy of 1 or 2 carbon atoms, and cyano, or (3) phenyl where the phenyl is unsubstituted or substituted with a substituent selected from the group consisting of methyl, chloro, and bromo in association with the animal's feed, water, salt rations, or pharmacologically acceptable carrier. Compositions comprising a compound of the above formula for daily administration or long acting forms are disclosed.
REFERENCES:
patent: 4140795 (1979-02-01), Boger et al.
patent: 4246283 (1981-01-01), Boger et al.
Killinger John J.
The Upjohn Company
Waddell Frederick E.
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