Animal derived cell with antigenic protein introduced therein

Details Animal derived cell with antigenic protein introduced therein Animal derived cell with antigenic protein introduced therein

1995-03-15

1997-10-14

Ketter, James

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

530350, C12N 506, C07K 1400

Patent

active

056771762

ABSTRACT:
This invention comprises animal derived cells, especially erythrocytes, which have been artificially modified (and referred to as engineered erythrocytes or RBCs) so as to incorporate in their plasma membranes an antigen, CD4 protein derived from lymphocytes) which will cause them to selectively seek out and fuse with other cells that are infected with a virus, especially the AIDS virus. These modified cells can be further altered so as to contain in their cytoplasm a cytotoxic agent which, after the cell has fused with a target cell, will result in the pooling of their respective cytoplasms and the death of both cells. Such modified cells can be used as a basis for an in vitro diagnostic assay involving cells derived from the blood of patients suspected of having AIDS.

REFERENCES:
patent: 5236835 (1993-08-01), Mouneimne et al.
Doxsey et al. An efficient method for introducing macromolecules into living cells J. Cell Biol. vol. 101 19-27 1985.
Maddon et al. The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: A new member of the immunoglobulin gene family Cell vol. 42 93-104 1985.
Gad et al. Fusion of cells and proteoliposomes: Incorporation of beef heart cytochrome oxidase into rabbit erythrocytes FEBS Lett. vol. 102 230-234 1979.
Mayhew et al. Therapeutic applications of liposomes Chapter 7 in Liposomes M.J. Ostro Ed. Marcel Dekker, New York and Basel. 1983.
Dimitriadis et al. Liposome-mediated ricin toxicity in ricin-resistant cells FEBS Lett. vol. 98 33-36 1979.
Yarchoan et al. Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex Lancet 575-580 Mar. 15, 1986.

Affiliated with

Also associated with

Rating

Animal derived cell with antigenic protein introduced therein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Animal derived cell with antigenic protein introduced therein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Animal derived cell with antigenic protein introduced therein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1554449