Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using a micro-organism to make a protein or polypeptide
Reexamination Certificate
2005-08-23
2005-08-23
Lilling, Herbert J. (Department: 1651)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using a micro-organism to make a protein or polypeptide
C435S084000, C435S104000, C435S252100, C435S253600
Reexamination Certificate
active
06933137
ABSTRACT:
Animal-free meninge fermentation media and process is developed based upon use of a chemically defined medium. To improve polysaccharide production, fed-batch fermentation is examined using different feed solutions and feeding strategies. A feed solution containing glucose, amino acids, and trace metal elements produces Group A polysaccharide at approximately 3 times the level observed with batch fermentation. This process is used successfully to produce polysaccharides ofN. meningitidisserotypes, A, C, Y and W-135 and is run reproducibly at the 20 L scale and can be scaled to 400 L or more.
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Fu, et al. Recent Advances in the large scale fermentation of Neisseria meningitidis . . . , Bio/Technology, Feb 1995, pp. 170-174, vol. 13.
Egen Richard C.
Fortin Lori Ann
Sun Willie Wei Qiang
Aventis Pasteur
Bordner Thomas J.
Lilling Herbert J.
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