Animal cell line useful for expression of exogenous genes

Details Animal cell line useful for expression of exogenous genes Animal cell line useful for expression of exogenous genes

1991-06-13

1993-10-19

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352402, 4351723, C12P 2102, C12N 510, C12N 1563

Patent

active

052544621

ABSTRACT:
The present invention relates to an animal cell line which is capable of growing in a substantially protein-free medium and has a substance capable of enhancing replication of exogenous genes.
The animal cell line according to the present invention can grow in a substantially protein-free medium and can replicate exogenous genes extrachromosomally. It is possible to easily produce a great amount of substances useful to mammals by using the transformant according to the present invention. Further, it is easy to collect and purify the substances useful to mammals, which are produced by using the transformant according to the present invention.

REFERENCES:
patent: 4741901 (1988-05-01), Levinson et al.
Tegtmeyer, J. Virol. vol. 15, 1975, pp. 613-618.
Pavlakis et al., from Gene Transfer Vectors for Mammalian Cells, 1987, Cold Spring Harbor Laboratory, pp. 29-38.
Cytotechnology, vol. 4, No. 3, Mar. 1990, pp. 279-283, R. Bliem, et al., "Antibody Production in Packed Bed Reactors Using Serum-Free and Protein-Free Medium".
Molecular & Cellular Biology, vol. 5, No. 3, Mar. 1985, pp. 563-568, H. Ariga, et al., "Cloned Mouse DNA Fragments Can Replicate in a Simian Virus 40 T Antigen-Dependent System in Vivo and in Vitro".
Gene, vol. 59, No. 2-3, 1987, pp. 231-239, U. H. Weidle, et al., "Establishment of a Temperature-Inducible Cell Line for Human Plasminogen Activator (Tissue-Type) by Transfection of Monkey Cells with Expression Constructs".
Gene, vol. 43, No. 3, 1986, pp. 237-245, F. G. Kern, et al., "An Inducible Eukaryotic Host-Vector Expression System: Amplification of Genes Under the Control of the Polyoma Late Promoter in a Cell Line Producing a Thermolabile Large . . . ".

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