Anilino-substituted isoquinoline quinones, pharmaceutical compos

Details Anilino-substituted isoquinoline quinones, pharmaceutical compos Anilino-substituted isoquinoline quinones, pharmaceutical compos

1982-09-30

1984-10-23

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424258, 546139, 546 14B, A61K 912, A61K 3147, C07D21702

Patent

active

044788207

ABSTRACT:
This invention relates to a class of isoquinoline quinones, which are useful for the therapy of immediate hypersensitivity reactions, such as asthma, and in treating any condition characterized by excessive release of leukotrienes. This invention also includes a method for treating these conditions, which comprises administering to animals, including humans, an effective dose of the isoquinoline quinone compounds. A further part of this invention is pharmaceutical formulations containing these pharmacologically-active compounds.

REFERENCES:
patent: 3491101 (1970-01-01), Allen, Jr. et al.
patent: 3857847 (1974-12-01), Gutzwiller et al.
patent: 4390541 (1983-06-01), Goldsworthy et al.
Lora-Tamayo, M., et al., Chem. Ber., 95, 2176-2181 (1962).
CA 68:12836u and Diss. Abstr. B., 28(1), 114-115.
CA 77:121481f.
Fleisch et al., J. Pharmacol. Exp. Ther., 209 238-243 (1979).
"Elusive Asthma-Related Molecule Synthesized", Chemical and Engineering News, Feb. 18, 1980, pp. 28-30.
Dahlen et al., "Allergen Challenge . . . Leukotrienes C.sub.4, D.sub.4 and E.sub.4 ", Proc. Natl. Acad. Sci., 80, 1712-1716 (1983).
Dahlen, "Pulmonary Effects of Leukotrienes", Acta Physiologica Scandinavica Supplementum 512 (1983).
Turnbull et al., Lancet, II, 526-529 (1977).
Cromwell et al., Lancet, II, 164-165 (1981).

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