Anilide derivatives as antidepressants

Details Anilide derivatives as antidepressants Anilide derivatives as antidepressants

1978-08-03

1980-08-12

Demers, Arthur P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260561B, 260562A, 424308, 424311, 424314, 424324, 260107, A61K 3124, C07C10338

Patent

active

042173620

ABSTRACT:
Anilide derivative compounds of the formula ##STR1## e.g., trans-N-(2-hydroxycyclopentyl)-3',4'-dichloropropionanilide, have been found to possess potent Central Nervous System (CNS) antidepressant properties.
These compounds are promising antidepressant drugs which are characterized by less toxicity than imipramine, and long-acting activity which may allow longer durations between administrations, e.g., once a day. Pharmaceutical compositions containing these compounds and a process for treating conditions of depression with these compositions are also disclosed.

REFERENCES:
patent: 3510492 (1970-05-01), Szmuszkovicz
patent: 3852058 (1974-12-01), Huffman
patent: 4098904 (1978-07-01), Szmuszkovicz
Gordon et al., The Chemists Companion, J. Wiley & Sons, N.Y., N.Y., 1972, pp. 144-155.

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