Anhydrous enhanced coupling of proteins

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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530389, 530387, 530405, 530409, 530807, 424 858, 436823, C07K 308, C07K 1706, A61K 39395

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048431478

ABSTRACT:
An improvement in a method to conjugate a protein which must resist denaturation with a variable component using a carbodiimide condensing agent utilizes a polar aprotic solvent as the medium for condensation. This improvement results in shorter reaction times and improved coupling efficiency.

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Mastrioanni et al., J. Phys. Chem., 76(21), 3050-3057, 1972.
Atassi et al., Bioch. Biophys. Acta., 670, 300-302, (1981).

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