Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1989-02-24
1990-12-11
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424455, A61K 950
Patent
active
049769685
ABSTRACT:
Substantially anhydrous pharmacological agents microencapsulated within protective hollow proteinoid microspheres are produced by contacting an aqueous mixture of such agent with an insoluble proteinoid and lyophilizing the resulting microspheres. Such encapsulation and dehydration results in a free flowing powder that has a long shelf life under naturally occurring temperature conditions and that quickly reabsorbs water without damage to the capsular wall. Gastrointestinally labile or poorly absorbed agents, such as insulin, heparin or dopamine redox carrier system, which are so microencapsulated in protective microspheres are rapidly rehydrated by body fluids in the gastrointestinal tract. Those microspheres having a diameter of about 10 microns or less penetrate the gastrointestinal mucosa and release the agent into the bloodstream in physiologically active form.
REFERENCES:
patent: 3052655 (1962-09-01), Fox et al.
patent: 3076790 (1963-02-01), Fox et al.
patent: 3576758 (1971-04-01), Emrick
patent: 3794561 (1974-02-01), Matsukawa et al.
patent: 3822348 (1974-07-01), Higashi et al.
patent: 3962416 (1976-06-01), Katzen
patent: 4061466 (1977-12-01), Sjoholm et al.
patent: 4217370 (1980-08-01), Rawlings
patent: 4272506 (1981-06-01), Schwarzberg
patent: 4351337 (1982-09-01), Sidman
patent: 4388304 (1983-06-01), Nyeki et al.
patent: 4492684 (1985-01-01), Goosen et al.
patent: 4647455 (1987-03-01), De Bold
patent: 4671954 (1987-06-01), Goldberg et al.
patent: 4703042 (1987-10-01), Bodor
patent: 4753804 (1988-06-01), Iaccheri et al.
patent: 4757024 (1988-07-01), Roper
patent: 4774320 (1988-09-01), Tagliabue et al.
patent: 4789734 (1988-12-01), Pierschbacher
patent: 4844904 (1989-07-01), Hamaguchi et al.
Przybylski and Fox, Appl. Biochem. Biotech. 10, 301-307 (1964).
Matsuno, BioSystems 17, 11-14 (1984).
Kokufuta, et al., BioSystems 16, 175-181 (1984).
Sun et al., Chemical Abstracts 105:12027p (Pharmaceuticals, vol. 105, 1986).
Clinical Technologies Associates, Inc.
Page Thurman K.
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