Anhydrous crystalline...

Details Anhydrous crystalline... Anhydrous crystalline...

2005-03-08

2005-03-08

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S934000, C514S894000, C536S028510, C536S028500, C536S055300

Reexamination Certificate

active

06864244

ABSTRACT:
The present invention relates to the hemisulfate salt of 1-[4(S)-azido-2(S),3(R)-dihydroxy-4-(hydroxymethyl)-1(R)-cyclopentyl]cytosine (Ia) with improved stability and physical properties which facilitate manufacturing, handling and formulating I and polymorphic crystalline forms thereof.

REFERENCES:
patent: 5449664 (1995-09-01), Verheyden et al.
patent: WO 0218404 (2002-03-01), None
patent: WO 02100415 (2002-12-01), None
Moffatt, J.G., “Chemical Transformations of the Sugar Moiety of Nucleosides”, Nucleoside Analogues, (R. T. Walker, E. De Clercq, & F. Eckstein, eds.), (1979), pp. 71-164, Plenum Press, New York. (see p. 144).
Maag, Hans, et al., “Synthesis and Anti-HIV Activity of 4′-Azido- and 4′- Methoxynucleosides,”J. Med. Chem., 1992, pp. 1440-1451, 35(8), (Table I).

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