Anhydrous crystal of 4-carbamoyl-1-.beta.-D-ribofuranosyl imidaz

Details Anhydrous crystal of 4-carbamoyl-1-.beta.-D-ribofuranosyl imidaz Anhydrous crystal of 4-carbamoyl-1-.beta.-D-ribofuranosyl imidaz

1994-04-21

1995-08-15

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 286, 536 287, 536 288, 435 85, 435911, C07H 19052

Patent

active

054420512

ABSTRACT:
Anhydrous crystals of 4-carbamoyl-1-.beta.-D-ribofuranosyl imidazolium-5-olate are disclosed. The crystals possess (1) water content of 0.5% by weight or less (the Karl Fisher method), and (2) specific IR spectrum absorption peaks in the neighborhoods of 3580, 1852, 1630, 1575, and 1554 cm.sup.-1. They are stable against heat and high humidity conditions and can easily be manufactured by using ethanol. The compound has superior immuno-suppressing activity and is thus made into preparations for oral administration.

REFERENCES:
patent: 3888843 (1975-06-01), Mizuno et al.
Chemical Abstracts, vol. 98, No. 25, 20th Jun. 1983, p. 437, abstract No. 214316w, Columbus, Ohio, US; & JP-A-58 13 395 (Ajinomoto Co., Inc.) 25 Jan. 1983 *Abstract*.
Journal of Antibiotics, vol. 27, No. 10, 1974, pp. 775-782; K. Mizuno et al: "Studies on bredinin. I. Isolation, characterization and biological properties" *The Whole Document*.
Chemical and Pharmaceutical Bulletin, vol. 23, No. 1, 1975, pp. 245-246; "Studies on bredinin. III. Chemical synthesis of bredinin (a novel imidazole nucleoside)" *The Whole Document*.
Chemical Abstracts, vol. 85, No. 1, 5th Jul. 1976, p. 317, abstract No. 3875e, Columbus, Ohio, US; & JP-A-76 01 693 (Toyo Jozo Co., Ltd.) 8 Jan. 1976 *Abstract*.

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