Anhydrous ampicillin stabilization and resultant compositions

Details Anhydrous ampicillin stabilization and resultant compositions Anhydrous ampicillin stabilization and resultant compositions

1975-08-21

1976-11-23

Turner, V. D.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Free from infectious agents

424271, A61K 3100, A61K 4700

Patent

active

039937534

ABSTRACT:
The formation of hydrates of anhydrous ampicillin in aqueous suspension may be retarded or entirely prevented for extended periods by (1) the addition of about 70 to 86% w/v of sucrose and (2) adjustment of the product pH to about 5.0 to 6.5. The invention is useful in extending the shelf life of aqueous dosage forms of anhydrous ampicillin.

REFERENCES:
patent: 3317389 (1967-05-01), Granatek et al.
patent: 3351527 (1967-11-01), Apat et al.
Physician's Desk Reference, 22nd Ed. (1968), pp. 582-583.

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