Angiotensinogen gene variants and predisposition to hypertension

Details Angiotensinogen gene variants and predisposition to hypertension Angiotensinogen gene variants and predisposition to hypertension

1994-07-01

1996-12-31

Jones, W. Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, 536 2433, 435 6, 935 8, 935 9, 935 78, C07H 2104, C12Q 168

Patent

active

055895840

ABSTRACT:
The association of molecular variants of the angiotensinogen gene with human essential hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.

REFERENCES:
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Kunapuli, S. P. and Kumar, A. (1986). "Difference in the Nucleotide Sequence of Human Angiotensinogen cDNA," Nucl. Acids Res. 14:7509.
Gaillard, I. et al. (1989). "Structure of Human Angiotensinogen Gene," DNA 8:87-99.
Fukamizu, A. et al. (1990). "Structure and Expression of the Human Angiotensinogen Gene," J. Biol. Chem. 265:7576-7582.
Soubrier, F. et al. (1990). "Similar Frequencies of Renin Gene Restriction Fragment Length Polymorphisms in Hypertensive and Normotensive Subjects," Hypertension 16:712-717.
Kotelevisev, Y. V. et al. (1991). "Dinucleotide Repeat Polymorphism in the Human Angiotensinogen Gene," Nucl. Acids Res. 19:6978.
Jeunemaitre, X. et al. (1992). "Absence of Linkage Between the Angiotension Converting Enzyme Locus and Human Essential Hypertension," Nature Genetics 1:72-75.
Jeunemaitre, X. et al. (1992). "Sib Pair Linkage Analysis of Renin Gene Haplotypes in Human Essential Hypertension," Human Genetics 88:301-306.
Jeunemaitre et al., Cell 71:167-180 (1992).

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