Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-12-06
1992-08-11
Springer, David B.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
544114, 544337, 544366, 546208, 546 22, 548111, 548252, 548215, 548376, C07D40306, C07D40312, C07D41306, C07D41212
Patent
active
051380692
ABSTRACT:
Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
REFERENCES:
patent: 3772315 (1973-11-01), Regel et al.
patent: 4207324 (1980-06-01), Matsumura et al.
patent: 4226878 (1980-10-01), Iizuka et al.
patent: 4301169 (1981-11-01), Yamanaka et al.
patent: 4328349 (1982-05-01), Grayboyes et al.
patent: 4340598 (1982-07-01), Furukawa et al.
patent: 4347364 (1982-08-01), Walser et al.
patent: 4347365 (1982-08-01), Walser et al.
patent: 4355040 (1982-10-01), Furukawa et al.
patent: 4379927 (1983-04-01), Vorbruggen et al.
patent: 4402966 (1983-09-01), Yamanaka et al.
patent: 4448781 (1984-05-01), Cross et al.
patent: 4463011 (1984-07-01), Ogata et al.
patent: 4532331 (1985-07-01), Frazee et al.
patent: 4533669 (1985-08-01), Yamanaka et al.
patent: 4602031 (1986-07-01), Yamanaka et al.
patent: 4689182 (1987-08-01), Rafferty et al.
patent: 4755518 (1988-07-01), Rafferty et al.
H. Torii, Takeda Kenkyushoho, 40, No. 3/4, 180-191 (1982).
Pals et al., Circulation Research, 29, 673 (1971).
Streeten and Anderson, Handbook of Hypertension, vol. 5, Clinical Pharmacology of Antihypertensive Drugs, A. E. Doyle (Editor), Elsevier Science Publishers B.V., p. 246 (1984).
Satoh, et al., Cir. Res. 36/37 & Suppl. I): I-89, 1975.
Blasingham et al., Am. J. Physiol., 239:F360, 1980.
Wong et al., Pharmacol. Exp. Ther., 215:104, 1980.
Dunn, Hospital Practice, 19:99, 1984.
Dzau et al., N. Eng. J. Med., 310:347, 1984.
Lindgren et al., Eur. J. Pharmacol., 135:383, 1987.
Zatz et al., Kidney International, vol. 31, Suppl. 20, pp. S-123-129 (1987).
Schmidt et al., J. Cardiovascular Pharmacology, vol. 8, pp. S100-105 (1986).
Wong et al., Abstract No. 30, Hypertension, p. 340, vol. 12, No. 3, Sep. 1988.
High Blood Pressure Council Mtg., San Francisco, Calif., Sep. 28-Oct. 1, 1988, "X-6803 Methyl 2-N-Butyl-1-(4-(2-Carboxybenzamido)Benzyl-4-Chloroimidazole-5-Acetate, Sodium Salt): A Novel Nonpeptide Angiotension II Receptor Antagonist".
Chiu et al., Abstract No. 118.11, The Pharmacologist, vol. 30, p. A165, 1988, for ASPET mtg., Montreal Canada, Oct. 9-13, 1988: "Nonpeptide Angiotensin II (AII) Receptor Antogonists: Structure Function Studies".
Wong et al., "Nonpeptide Angiotensin II Receptor Antognists. I. Pharmacological Characterization of 2-n-Butyl-chloro-1-(2-chlorobenzyl)imidazole-5-acetic acid, sodium salt (S-8307)", J. Pharmacology and Experimental Therapeutics, vol. 247, No. 1, pp. 1-7.
Chiu et al., "Non-peptide angiotensin II Receptor antognists. II. Pharmacology of S-8308", European Journal of Pharmacology, vol. 157, pp. 13-21 (1988).
Carini David J.
Duncia John J. V.
Wong Pancras C. B.
E. I. Du Pont de Nemours and Company
Springer David B.
LandOfFree
Angiotensin II receptor blocking imidazoles does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Angiotensin II receptor blocking imidazoles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Angiotensin II receptor blocking imidazoles will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-347758