Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-01-07
1989-11-14
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514253, 514322, 514374, 514381, 514394, 544139, 544370, 546199, 548215, 548252, 548253, 548325, 548327, 548330, A61K 31535, C07D23356
Patent
active
048808040
ABSTRACT:
Substituted benzimidazoles such as ##STR1## and pharmaceutically suitable salts thereof are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
REFERENCES:
patent: 3772315 (1973-11-01), Regel et al.
patent: 3821393 (1974-06-01), Janiak et al.
patent: 4207324 (1980-06-01), Matsamura et al.
patent: 4226878 (1980-10-01), Ilzuka et al.
patent: 4328349 (1982-05-01), Grayboyes et al.
patent: 4340598 (1982-07-01), Furukawa et al.
patent: 4347364 (1982-08-01), Walser et al.
patent: 4347365 (1982-08-01), Walser et al.
patent: 4355040 (1982-10-01), Furukawa et al.
patent: 4379927 (1983-04-01), Vorbruggen
patent: 4448781 (1984-05-01), Cross et al.
patent: 4463011 (1984-07-01), Ogata et al.
patent: 4612323 (1986-09-01), Kisida et al.
patent: 4663339 (1987-05-01), Kisida et al.
H. Torii et al., Takeda Kenkyushoho, 41, No. 3/4, 180-191 (1982).
D. Pals et al., Circulation Research, 29, 673 (1971).
Streeten & Anderson, Handbook of Hypertension, vol. 5, Clinical Pharmacology of Antihypertensive Drugs, A. E. Doyl (Ed.), Elsevier Science Publishers, B. V., p. 246 (1984).
Satoh et al., Circ. Res., 36/37 (Suppl. I):1-89, 1975.
M. Blasingham et al., Am. J. Physiol., 239:F60, 1980.
P. Wong et al., Pharmacol. Exp. Ther., 215:104, 1980.
M. Dunn, Hospital Practice, 19:-9, 1984.
V. Dzau et al., N. Eng. J. Med., 310:347, 1984.
B. Lindgren et al., Eur. J. Pharmacol., 135:383, 1987.
R. Zatz et al., Kidney International, vol. 31, Suppl. 20, pp. S-123 to S-129.
P. Wong et al., Life Sciences, vol. 27, pp. 1291-1297 (1980).
M. Schmidt et al., J. Cardiovascular Pharmacology, vol. 8, pp. S100-S105 (1986).
Carini David J.
Duncia John Jonas V.
Yoo Sung-Eun
E. I. Du Pont de Nemours and Company
Schwartz Richard A.
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