Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-04-25
2011-11-08
Saeed, Kamal (Department: 1622)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S253000
Reexamination Certificate
active
08053455
ABSTRACT:
A compound having the structurewherein R is an angiotensin receptor antagonist active group,Y is selected from the group consisting ofandin-line-formulae description="In-line Formulae" end="lead"?—C(R1H)OC(O)X((CR12R13)—(CHR10)m—(CH2)n—Zp—(CH2)q—(CHR11)r—(CR16R17))—R5; 2)in-line-formulae description="In-line Formulae" end="tail"?Z is —O— or —(CR14R15)—;m, n, p, q, and r are independently selected from the group consisting of 0 and 1;X is —O— or —(CR18R19)—;R1is selected from the group consisting of hydrogen, C1-4alkyl, aryl and C1-4alkylaryl;R5is —O—N═N(O)—R3R4;or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.
REFERENCES:
patent: 5138069 (1992-08-01), Carini et al.
patent: 5366997 (1994-11-01), Keefer et al.
US International Search Report; completed Feb. 24, 2009; Performed by Authorized Officer Lee W. Young.
Ali Amjad
Franklin Christopher
Lo Michael Man-Chu
Whitehead Brent
Bianchi Kristin
Daniel Mark R.
Merck Sharp & Dohme Corp.
Parr Richard S.
Saeed Kamal
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