Angiotensin II antagonizing fused pyridinyloxy containing deriva

Details Angiotensin II antagonizing fused pyridinyloxy containing deriva Angiotensin II antagonizing fused pyridinyloxy containing deriva

1992-02-11

1993-03-30

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142338, 5142345, 514300, 514301, 514302, 540523, 540580, 544127, 544238, 544333, 544362, 544405, 546113, 546114, 546116, 546122, 546123, A61K 31435, C07D47104, C07D491052

Patent

active

051984342

ABSTRACT:
The invention concerns pharmaceutically useful compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, n, m, X, Y and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.

REFERENCES:
patent: 4880804 (1989-11-01), Carini et al.
patent: 4920131 (1990-04-01), Huang et al.
patent: 5028615 (1991-06-01), Huang et al.
patent: 5126344 (1992-06-01), Roberts et al.
patent: 5130318 (1992-07-01), Roberts et al.
G. R. Proctor, et al., "Azabenzocycloheptenones. Part XIV. Cyclisation of Amino-acid Derivatives to Tetrahydro-1-benzazepin-5-ones and Tetrahydroquinolin-4-ones" J. Chem. Soc., Perkin Trans. I (1972), 1803-8.
R. D. Youssefyeh, et al. (principal author Huang) J. Med. Chem. (1990), 33, 1186-1194; Chem. Abstr. (1990), 112, 17, abstract 131,890u.
F-C. Huang J. Med. Chem. (1990), 33, 1194-1200.

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