Angiotensin II antagonizers which are condensed pyridine derivat

Details Angiotensin II antagonizers which are condensed pyridine derivat Angiotensin II antagonizers which are condensed pyridine derivat

1991-04-18

1992-07-14

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514312, 546153, 546156, 546183, A61K 3147, A61K 31435, C07D215233, C07D22102

Patent

active

051303183

ABSTRACT:
The invention concerns pharmaceutically useful novel compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.

REFERENCES:
patent: 4820843 (1989-04-01), Aldrich et al.
patent: 4880804 (1989-11-01), Carini et al.
G. R. Proctor, et al., J. Chem. Soc., Perkin Trans. I (1972) (14), 1803-8.

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