Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-08-19
1994-08-16
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514397, 514401, 514402, 514396, 514468, 514406, 514841, 546118, A61K 31415, A61K 3134
Patent
active
053387449
ABSTRACT:
The present invention relates to the use of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acids and analogs thereof in antagonizing the binding of angiotensin II to AT.sub.2 receptors.
REFERENCES:
patent: 4812462 (1989-03-01), Blankley et al.
Bumpus et al., Hypertension, 1991, 17, 720-721, "Nomenclature for Angiotensin Receptors".
Dudley et al., Molecular Pharmacology, 1990, 38, 370-377, "Subclass of Angiotensin II Binding Sites and Their Functional . . . ".
Pucell et al., Endocrinology, 1991, 128, 1947-1959, "Biochemical Properties of the Ovarian Granulosa Cell Type 2-Angiotensin II . . . ".
Andrade-Gordon et al., Biochemical Pharmacology, 1991, 42, 715-719, "Role of Angiotensin II in the Processes Leading to Ovulation".
Speth et al., Peptide Research, 1989, 2, 232-239, "Angiotensin II Receptor Binding and Actions in NG108-15 Cells".
Tallant et al., Hypertension, 1991, 17, 1135-1143, "Identification and Regulation of Angiotensin II Receptor Subtypes on NG108-15 Cells".
Chemical Abstracts: vol. 113 (25) #225090f (1990).
Dudley David T.
Hodges John C.
Pugsley Thomas A.
Taylor Michael D.
Ashbrook Charles W.
Atkins Michael J.
Cintins Marianne M.
Criares T. J.
Warner-Lambert & Company
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