Angiotensin converting enzyme inhibitor

Details Angiotensin converting enzyme inhibitor Angiotensin converting enzyme inhibitor

2006-04-25

2006-04-25

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S016700, C514S017400, C514S018700, C514S019300, C514S020800, C530S328000, C530S329000, C530S330000, C530S331000, C435S070100

Reexamination Certificate

active

07034002

ABSTRACT:
The present invention provides an angiotensin converting enzyme inhibitor having strong activity of inhibiting angiotensin converting enzyme, good hue and easily to take in which is a composition containing peptides obtained by digesting a fish meat with thermolysin enzyme, and wherein a content of a polypeptide ingredient having a molecular weight of at least 5000 is at most 10% by weight.

REFERENCES:
patent: 5314807 (1994-05-01), Yoshikawa et al.
patent: 5369015 (1994-11-01), Yoshikawa et al.
patent: 6-298794 (1994-10-01), None
Yokoyama et al. “Peptide Inhibitors for Angiotensin I-Converting Enzyme From Thermolysin Digest of Dried Bonito.” Biosci. Biotech. Biochem. vol. 56, No. 10, pp. 1541-1545, 1992.
Patent Abstracts of Japan, vol. 016, No. 273 (C-0953), Jun. 18, 1992 & 04069398 A (Nippon Synthetic Chemind Co. Ltd: The), Mar. 4, 1992.
File Caplus on Stn. Dn No. 123:65813. JP 06340692, Dec. 13, 1994. Abstract date 1995. Abstract only.
“Peptide Inhibitors for Angiotensin I-Converting Enzyme from Thermolysin Digest of Dried Bonito” Bioscience Biotechnology, Biochemistry, Japan Soc. for Bioscience, Biotechnology and Agrochem. Tokyo, JP, vol. 56, No. 10, 1992, pp. 1541-1545, XP000973744.
Patent Abstracts of Japan, vol. 1995, No. 01, Feb. 28, 1995 & JP 06 298794 A (Nippon Synthetic Chemind Co Ltd: The), Oct. 25, 1994.
Patent Abstracts of Japan, vol. 016, No. 411 (C-0979), Aug. 31, 1992 & JP 04 139196 A (Nippon Synthetic Chemind Co Ltd: The), May 13, 1992.
Patent Abstracts of Japan, vol. 016, No. 273 (C-0935), Jun. 18, 1992 & JP 04 069398 A (Nippon Synthetic Chemind Co Ltd: The), Mar. 4, 1992.
“LKPNM: a prodrug-type ACE-inhibitory peptide derived from fish protein” Immunopharmacology, Elsevier Science Publishers BV, XX, vol. 44, Oct. 15, 1999, pp. 123-127, XP000973860.

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