Angiotensin-converting enzyme inhibiting dipeptide derivatives

Details Angiotensin-converting enzyme inhibiting dipeptide derivatives Angiotensin-converting enzyme inhibiting dipeptide derivatives

1982-05-14

1986-10-14

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

560 44, 560457, 530800, 562457, A61K 3743, C07K 506, C07C10144

Patent

active

046172912

ABSTRACT:
Dipeptides having the formula ##STR1## wherein A is halogen, hydrogen, lower alkyl, or lower alkoxy; B is hydrogen or lower alkyl, or A and B are taken together to form an ortho-methylene or ethylene bridge; R is hydrogen, lower alkyl, or phenylalkyl; and X.sup.1 and X.sup.2 are independently chosen from hydroxy or lower alkoxy; are inhibitors of angiotensin-converting enzyme and can be used for the treatment of hypertension in mammals.

REFERENCES:
patent: 4303583 (1981-12-01), Kim et al.
patent: 4344949 (1982-08-01), Hoefle et al.
patent: 4404206 (1983-09-01), Vincent et al.

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