Angiotensin converting enzyme homolog and uses therefor

Details Angiotensin converting enzyme homolog and uses therefor Angiotensin converting enzyme homolog and uses therefor

2005-04-26

2005-04-26

Tate, Christopher R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C530S350000, C530S361000, C424S094100, C424S094600, C435S183000, C435S195000

Reexamination Certificate

active

06884771

ABSTRACT:
The present invention relates to the discovery of novel genes encoding an angiotensin converting enzyme, Angiotensin Converting Enzyme-2 (ACE-2). The invention provides therapeutics, prognostic and diagnostics methods for treating blood pressure related disorders as well as various types of allergic conditions, among others. Also disclosed are screening assays for identifying compounds for treating and preventing these conditions.

REFERENCES:
patent: 0 974 664 (2000-01-01), None
patent: WO 0018899 A2 (2000-04-01), None
DGENE Accession No. AAY 84562 for “A human angiotensin converting enzyme-2 (ACE-2) protein,” Jul. 25, 2000.
DGENE Accession No. AAA12764 for “cDNA encoding a human angiotensin converting enzyme-2 (ACE-2),” Jul. 25, 2000.
DGENE Accession No. AAY67310 for “Human MPROT15 amino acid sequence #1,” Apr. 11, 2000.
DGENE Accession No. AAZ59465 for “Human MPROT15 coding sequence #1,” Apr. 11, 2000.
EMBL Accession No. AF241254 for “Homo sapiensangiotensin converting enzyme-like protein mRNA, complete cds,” Jul. 1, 2000.
SWALL Accession No. Q9NRA7 for “Angiotensin converting enzyme-like protein (ACE-related carboxypeptidase ACE2)”, Oct. 1, 2000.
Bernstein, K. E. “Two ACEs and a heart,”NatureJun. 20, 2002; 417:799,801-802.
Donoghue, M. et al. “A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9,”Circulation ResearchSep. 1, 2000; 87(5):e1-e9.
Tipnis, S.R. et al. “A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase,”Journal of Biological ChemistryOct. 27, 2000; 275(43):33238-33243.

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