Angiostatin protein

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C435S069100, C435S252300, C435S320100, C536S032000

Reexamination Certificate

active

07365159

ABSTRACT:
The present invention provides plasminogen fragments containing kringle region domains having anti-angiogenic activity and termed angiostatin protein. The plasminogen fragments of the present invention may be used for the treatment of angiogenesis-dependent diseases such as cancer.

REFERENCES:
patent: 5639725 (1997-06-01), O'Reilly et al.
patent: 5733876 (1998-03-01), O'Reilly et al.
patent: 5776704 (1998-07-01), O'Reilly et al.
patent: 5792845 (1998-08-01), O'Reilly et al.
patent: 5801146 (1998-09-01), Davidson
patent: 5837682 (1998-11-01), O'Reilly et al.
patent: 5854221 (1998-12-01), Cao et al.
patent: 5861372 (1999-01-01), Folkman et al.
patent: 5885795 (1999-03-01), O'Reilly et al.
patent: 5945403 (1999-08-01), Folkman et al.
patent: 5972896 (1999-10-01), Davidson
patent: 5981484 (1999-11-01), Davidson
patent: 6024688 (2000-02-01), Folkman et al.
patent: 6057122 (2000-05-01), Davidson
patent: 6251867 (2001-06-01), Davidson
patent: 6521439 (2003-02-01), Folkman et al.
patent: 58036391 (1983-03-01), None
patent: WO 90/13640 (1990-11-01), None
patent: WO 91/09118 (1991-06-01), None
patent: WO 91/10424 (1991-07-01), None
patent: WO 93/16716 (1993-09-01), None
patent: WO 95/25543 (1995-09-01), None
patent: WO 95/29242 (1995-11-01), None
Abe, N. et al., Identification of a Novel Collagen Chain Represented by Extensive Interruptions in the Triple-Helical Region,Biochemical and Biophysical Research Communications, vol./Iss: 196 (2), pp. 576-582, Oct. 29, 1993.
Algire, G.H. et al., Vascular reactions of normal and malignant tumors in vito. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants,Journal of the National Cancer Institute, vol./Iss: 6, pp. 73-85, Aug. 1945.
Angiolillo, A. et al., Human Interferon-inducible Protein 1O is a Potent Inhibitor of Angiogenesis in Vivo.,The Journal of Experimental Medicine, vol./Iss: 182, pp. 155-162, Jul. 1995.
Berglund et al.,International Dairy Journal, vol./Iss: 5, pp. 593-603, 1995.
Brem, H. et al., Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas,Journal of Neurosurgery, vol./Iss: 74, pp. 441-446, Mar. 1, 1991.
Brockway, W. J. et al., Measurement of the Binding of Antifibrinolytic Amino Acids to Various Plasminogens,Archives of Biochemistry and Biophysics, vol./Iss: 151, pp. 194-199, Apr. 18, 1972.
Brooks, P.C. et al., Integrin αvβ3antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels,Cell, vol./Iss: 79, pp. 1157-1164, Dec. 30, 1994.
Browne, Expression of Recombinant Human Plasminogen and Aglycoplasminogen in HeLa cells,Fibinolysis, vol./Iss: 5, pp. 257-260, Apr. 13, 1991.
Cao, Y. et al., gro-B, a-C-X-C- Chemokine, is an Angiogenesis Inhibitor that Suppresses the Growth of Lewis Lung Carninoma In Mice,Journal of Experimental Medicine, vol./Iss: 182, pp. 2069-2077, Dec. 1, 1995.
Cao, Y. et al., Human acidic fibroblast growth factor overexpressed in insect cells is not secreted into the medium,Growth Factors, vol./Iss: 3(1), pp. 1-13, 1990.
Cao, Y. et al., Kringle Domains of Human Angiostatin,The Journal of Biological Chemistry, vol./Iss. 271 (46), pp. 29461-29467, Nov. 15, 1996.
Chen, C. et al., A Strategy to Discover Circulating Angiogenesis Inhibitors Generated by Human Tumors,Cancer Research, vol./Iss: 55, pp. 4230-4233, Oct. 1, 1995.
Church, W.R. et al., A Kringle-Specific Monoclonal Antibody,Hybridoma, vol.Iss: 13(5), pp. 423-429, Oct. 1, 1994.
Clapp, C. et al., The 16-Kilodalton N-terminal Fragment 6 Human Prolactin is a Potent Inhibitor of Angiogenesis,Endocrinology, vol./Iss: 133, pp. 1292-1299, Mar. 1, 1993.
Clare, J.J. et al., Production of mouse epidermal growth factor in yeast: High-level secretion usingPichia pastorisstrains containing multiple gene copies,Gene, vol./Iss: 105, pp. 205-212, 1991.
Cleary, S. et al., Purification and Characterization of Tissue Plasminogen Activator KringleDomain Expressed inEscherica coli, Biochemistry, vol./Iss. 28, pp. 1884-1891, 1989.
Curti, Brendan D., Physical barriers to drug delivery in tumors,Critical Reviews in Oncology/Hematology, vol./Iss: 14, pp. 29-39, 1993.
D'Angelo, G. et al., Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin,Proceedings of the National Academy of Science USA, vol./Iss: 92, pp. 6374-6378, Jul. 1995.
Dameron, K.M. et al., Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1,Science, vol./Iss: 265, pp. 1582-1584, Sep. 9, 1994.
Degen et al., Characterization of the cDNA Coding for Mouse Plasminogen and Localization of the Gene to Mouse Chromosome 17,Genomics, vol./Iss: 8, pp. 49-61, 1990.
Donate et al., Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGFI/MSP),Protein Science, vol./Iss: 3, pp. 2378-2394, 1994.
Fidler et al., The Implications of Angiogenesis for the Biology and Therapy of Cancer Metastasis,Cell, vol./Iss: 79(2), pp. 185-188, Oct. 21, 1994.
Folkman, J., Tumor Angiogenesis and Tissue Factor,Nature Medicine, vol./Iss: 2, pp. 167-168, Feb. 1, 1996.
Folkman, J., What is the Evidence that Tumors are Angiogenesis Dependent?,Journal of the National Cancer Institute, vol./Iss: 82 (1), pp. 4-6, Jan. 3, 1990.
Folkman, J., Angiogenesis in Cancer, Vascular, Rheumatoid and Other Disease,Nature Medicine, vol./Iss: 1(1), pp. 27-31, Nov. 1, 1995.
Folkman, J., Angiogenesis and Its Inhibitors,Important Advances in Oncology, pp. 42-62, 1985.
Folkman, J., Tumor Angiogenesis: Therapeutic Implications,New England Journal of Medicine, vol./Iss: 285 (21), pp. 1182-1186, Nov. 18, 1971.
Folkman, J. et al., Long-term Culture of Capillary Edothelial Cells,Proceedings of the National Academy of Science USA, vol./Iss: 76, pp. 5217-5221, Oct. 1, 1979.
Folkman, J. et al., Induction of Angiogenesis During the Transition from Hyperplasia to Neoplasia,Nature, vol./Iss: 339, pp. 58-61, May 4, 1989.
Folkman, J. et al., Tumor Behavior in Isolated Perfused Organs in vitro Growth and Metastases of Biopsy Material in Rabbit Thyroid and Canine Intestinal Segment,Annals of Surgery, vol./Iss: 164(3), pp. 491-502, Sep. 1, 1966.
Folkman, Judah, Clinical Applications of Research on Angiogenesis,The New England Journal of Medicine, vol./Iss: 333 (26), pp. 1757-1763, Dec. 28, 1995.
Forsgren, M. et al., Molecular cloning and characterization of a full-length cDNA clone for human plasminogen,FEBS Letters, vol./Iss: 213(2), pp. 254-260, Mar. 1987.
Friedlander, M. et al., Definition of two angiogenic pathways by distinctα, inetegrins,Science, vol./Iss: 270, pp. 1500-1502, Dec. 1, 1995.
Gavrieli, Y. et al., Identification of Programmed Cell Death in Situ via Specific Labeling of Nuclear DNA Fragmentation,Journal of Cell Biology, vol./Iss: 119, pp. 493-501, 1992.
Gimbrone, M.A. et al., Tumor Growth and Neovascularization: An Experimental Model Using the Rabbit Cornea,Journal of the National Cancer Institute, vol./Iss: 52(2), pp. 413-427, Feb. 1974.
Gimbrone, M.A. et al., Tumor dormancy in vivo by Prevention of Neovascularization,Journal of Experimental Medicine, vol./Iss: 136, pp. 261-276, 1972.
Glaser, Vicki, Targeted Injectable Vectors Remain the Ultimate Goal in Gene Therapy,Genetic Engineering News, pp. 8-9, 29, Apr. 15, 1994.
Gonzalez-Gronow et al., The role of carbohydrate in the function of human plasminogen: comparison of the protein obtained from molecular cloning and expression inEscherichia cαlnd COS cells,Biochemica et Biophysica Acta, vol./Iss: 1039, pp. 269-276, 1990.
Good, D.J. et al., A Tumor Suppressor-dependent Inhibitor of 6 Angiogenesis is Immunologically and Functionally Indistinguishablefrom a Fragment of Thombospondin,Proceedings of the National Academy of Science USA, vol./Iss: 87, pp. 6624-6628, Sep. 1990.
Grant, D.S. et al., Scatter factor induces blood vessel formation in vivo,Proceedings of the National Academy of Science USA, vol./Iss: 99, pp. 1937-1941, Mar. 1993.
Grant, D.S. et al., Two Different Laminin

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