Angiostatic steroids and methods and compositions for controllin

Details Angiostatic steroids and methods and compositions for controllin Angiostatic steroids and methods and compositions for controllin

1996-05-06

1997-12-16

Prior, Kimberly J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514182, A61K 3157

Patent

active

056985452

ABSTRACT:
Angiostatic steroids for use in controlling ocular hypertension are disclosed. Pharmaceutical compositions of the angiostatic steroids and methods for their use in treating ocular hypertension, including controlling the ocular hypertension associated with primary open angle glaucoma, are disclosed. In addition, the combination of the compounds with glucocorticoids for the prevention of elevated IOP during the treatment of inflammation is disclosed.

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patent: 5371078 (1994-12-01), Clark et al.
Crum, et al., Science, vol. 230, pp. 1375-1378 (Dec. 1985), "A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment".
Ingber, et al., Endocrinology, vol. 119, pp. 1768-1775 (1986), "A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids" Induction of Capillary Basement Membrane Dissolution.
Southern, et al., Investigative Ophthalmology and Visual Science, vol. 28, pp. 901-903 (May 1987), "Intraocular Hypotensive Effect of a Topically Applied Cortisol Metabolite: 3-alpha-5, beta-tetrahydrocortisol".
Folkman, et al., Ann. Surg., vol. 206(3):, pp. 374-382, (1987), "Angiostatic Steroids".
Rohen, Johanness W., Ophthalmology, vol. 90(7), pp. 758-764, (1983), "Why is Intraocular Pressure Elevated in Chronic Simple Glaucoma?".
Knepper, et al., Pediatric Neuroscience, vol. 12, pp. 240-251, (1985/86), "Glycosaminoglycans and Outflow Pathways of the Eye and Brain".

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