Angiostatic steroids

Details Angiostatic steroids Angiostatic steroids

1997-08-27

2000-01-04

Kelly, C. H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

552501, 552585, 552592, A01N 4500, C07J 5300, C07J 500, C07J 700

Patent

active

060110236

ABSTRACT:
Methods and compositions for preventing and treating neovascularization with steroids is disclosed.

REFERENCES:
patent: 4771042 (1988-09-01), Braughler et al.
patent: 4863912 (1989-09-01), Southren et al.
patent: 4876250 (1989-10-01), Clark
patent: 4945089 (1990-07-01), Clark et al.
patent: 4975537 (1990-12-01), Aristoff et al.
patent: 4997826 (1991-03-01), Southren et al.
patent: 5371078 (1994-12-01), Clark et al.
patent: 5407926 (1995-04-01), Clark
patent: 5679666 (1997-10-01), Clark
patent: 5719167 (1998-02-01), Doshi et al.
Crum, et al., A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment, Science, vol. 230, pp. 1375-1378 (Dec. 20, 1985).
Ingber, et al., A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids: Induction of Capillary Basement Membrane Dissolution, Endocrinology vol. 119, pp. 1768-1775 (1986).
Li, et al., Angiostatic Steroids Potentiated by Sulphated Cyclodextrin Inhibit Corneal Neovascularization, Investigative Opthalmology and Visual Science, vol. 32, No. 11, pp. 2898-2905 (Oct., 1991).
Southren, et al., Intraocular Hypotensive Effect of a Topically Applied Cortisol Metabolite: 3-.varies., 5-.beta. tetrahydrocortisol, Investigative Ophthalmology and Visual Science, vol. 28, (May, 1987).
Folkman, et al., Angiostatic Steroids, Ann. Surg., vol. 206, No. 3 (1987).
Kitazawa, Increased Intraocular Pressure Induced by Corticosteroids, Am. J. Ophthal., vol. 82 pp. 492-493 (1976).
Cantrill, et al., Comparison of In Vitro Potency of Corticosteroids with Ability to Raise Intraocular Pressure, Am. J. Ophthal., vol. 79 pp. 1012-1016 (1975).
Mindel, et al., Comparative Ocular Pressure Elevation by Medrysone, Fluorometholone, and Dexamethasone Phosphate, Arch. Ophthal., vol. 98 pp. 1577-1578 (1980).
Furcht, Critical Factors Controlling Angiogenesis: Cell Products, Cell Matrix, and Growth Factors Laboratory Investigation, vol. 55, No. 5, pp. 505-509 (1986).
Cariou, et al., Inhibition of Human Endothelial Cell Proliferation by Heparin and Steroids, Cell Biology International Reports, vol. 12, No. 12, pp. 1037-1047 (Dec., 1988).
Tokida, et al., Production of Two Variant Laminin Forms by Endothelial Cells and Shift of Their Relative Levels by Angiostatic Steroids, The Journal of Biological Chemistry, vol. 264, No. 30, pp. 18123-18129 (Oct. 25, 1990).
Maragoudakis, et al., Antiangiogenic Action of Heparin Plus Cortisone is Associated with Decreased Collagenous Protein Synthesis in the Chick Chorioallantoic Membrane System, The Journal of Pharmacology and Experimental Therapeutics, vol. 251, No. 2, pp. 679-682 (1989).
Ashino-Fuse, et al., Medroxyprogesterone Acetate, An Anti-Cancer and Anti-Angiogenic Steroid, Inhibits the Plasminogen Activator in Bovine Endothelial Cells, Int. J. Cancer, 44, pp. 859-864 (1989).
BenEzra, Neovasculogenic Ability of Prostaglandins, Growth Factors, and Synthetic Chemoattractants, American Journal of Ophthalmology, vol. 86, No. 4, pp. 455-461, (Oct., 1978).
Rohen, Johanness W., Why is Intraocular Pressure Elevated in Chronic Simple Glaucoma?, Ophthalmology, vol. 90(7), pp. 758-764, (1983).
Knepper, et al., Glycosaminoglycans and Outflow Pathways of the Eye and Brain, Pediatric Neuroscience, vol. 12, pp. 240-251, (1985/86).
Folkman et al., Angiogenic Factors, Science, vol. 235, pp. 442-447 (1987).
Johnson, et al., Glaucoma: An Overview, Mayo Clin. Proc., vol. 61, pp. 59-67 (Jan. 1986).

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