Angiostatic compounds

Details Angiostatic compounds Angiostatic compounds

1996-05-09

1998-08-25

MacMillan, Keith D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514458, A61K 31495

Patent

active

057983569

ABSTRACT:
The present invention is directed to compositions containing angiostatic compounds and methods for their use in preventing pathological neovascularization.

REFERENCES:
patent: 4550022 (1985-10-01), Garabedian et al.
patent: 5114957 (1992-05-01), Hendler et al.
patent: 5156852 (1992-10-01), La Haye et al.
patent: 5371078 (1994-12-01), Clark et al.
patent: 5424321 (1995-06-01), Hellberg et al.
patent: 5431907 (1995-07-01), Abelson et al.
patent: 5602183 (1997-02-01), Martin et al.
Oikawa, et al., "Inhibition of angiogenesis by vitamin D.sub.3 analogues", European Journal of Pharmacology, vol. 178, pp. 247-250 (1990).
Folkman, et al., "Angiogenic Factor", Science, vol. 235, pp. 442-447 (1987).
Furcht, "Critical Factors Controlling Angiogenesis: Cell Products, Cell Matrix, and Growth Factors", Laboratory Investigation, vol. 55, No. 5, pp. 505-509 (1986).
BenEzra, "Neovasculogenic Ability of Prostaglandins, Growth Factors, and Synthetic Chemoattractants", American Journal of Ophthalmology, vol. 86, No. 4, pp. 455-461 (1978).
Crum, et al., "A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment", Science, vol. 230, pp. 1375-1378 (1985).
Kitazawa, "Increased Intraocular Pressure Induced By Corticosteroids", American Journal of Ophthalmology, vol. 82, No. 3, pp. 492-495 (1976).
Taylor, et al., "Protamine is an inhibitor of angiogenesis", Nature, vol. 297, pp. 307-312 (1982).
Diaz-Flores, et al., "Angiogenesis: an update", Histol Histopath, vol. 9, pp. 807-843 (1994).
Seddon, J., et al., "Dietary Carotenoids, Vitamins A, C, and E, and Advanced Age-Related macular Degeneration", JAMA, vol. 272, No. 18, pp. 1413-1420 (1994).
Freshney, R. I., Culture of Animal Cells, 3rd Edition, John Wiley and Sons, New York, NY, pp. 277-278 (1994).
McNatt, et al., "Angiostatic Activity And Metabolism Of Cortisol In The Choroallantoic Membrane (CAM) Of The Chick Embryo", Journal of Steroid Biochemistry and Molecular Biology, vol. 42, No. 7, pp. 687-693 (1992).
BenEzar, D., et al., The Rabbit Cornea--A Model For The Study of Angiogensic Factors, in Ocular Circulation and Neovascularization, Documenta Opthalmalogia, Proceedings Series 50, pp. 335-340 (1987).
BenEzar, D., "Thrombospondin and In Vivo Angiogenesis Induced by Basic Fibroblast Growth Factor or Lipopolysaccharide", Investigative Opthalmology and Visual Sciences, vol. 34, No. 13, pp. 3601-3608 (1993).
Cohen, N., et al., "Lewis Aid Mediated Nucleophilic Substitution Reactions of 2-Alkoyxy-3, 4-dihydro-2H-1-benzopyrans: Regiochemistry and Utility in the Synthesis of 3,4-Dihydro-2H-1-benzopyran-2-carboxylic Acids",Journal of Organic Chemistry,vol. 54, pp. 3282-3292 (1989).
ElAttar, T. M., et al., "Vitamin E. Succinate Potentiates the Inhibitory Effect of Prostaglandins on Oral Squamous Carcinoma Cell Proliferation", Prostaglandins Leukotrines and Essential Fatty Acids, vol. 52, No. 1, pp. 69-73 (1995).
Fariss, M. W., et al., "The Selective Antiproliferative Effects of .alpha.-Tocopheryl Hemisuccinate and Cholesteryl Hemisuccinate on Murine Leukemia Cells Result from the Action f the Intact Compounds", Cancer Research, vol. 54, No. 13, pp. 3346-3351 (1994).
Bienfang, D. C., et al., Medical Progress--Ophthalmology, New England Journal of Medicine, vol. 323, p. 956-967 (1990).
Billington, D., "Angiogenesis and its inhibition: potential new therapies in oncology and non-neoplastic diseases", Drug Design and Discovery, vol. 8, pp. 3-35 (1991).
Doctrow, S., et al., "Angiogenesis Modulators--New Drugs for Controlling Blood Vessel Growth?", DN&P, vol. 2, No. 2, pp. 74-81 (1989).
Kretzer, F., et al., "Vitamin E protects against retinopathy of prematurity through action on spindle cells", Nature, vol. 309, pp. 793-795 (1984).
Moses, M., et al., "Inhibitors of Angiogenesis", Bio/Technology, vol. 9, pp. 630-634 (1991).

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