Angiostatic agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514824, 514863, 514866, 536 11, 536112, 536118, 536122, A61K 906, A61K 31715

Patent

active

051359200

ABSTRACT:
Dextran sulfate, .beta.-1,3-glucan sulfate, and the salts thereof are angiostatic and useful for treatment and prevention of various diseases caused by abnormally accelerated angiogenesis. Combination of such a compound with a steroidal or non-steroidal substance increases the angiostatic activity of each compound to induce the combined effect.

REFERENCES:
patent: 3754925 (1973-08-01), Kimura et al.
patent: 4207312 (1980-06-01), Fujii et al.
patent: 4767614 (1988-08-01), Scarpa et al.
patent: 4793336 (1988-12-01), Wang
patent: 4820693 (1989-04-01), Gillespie
patent: 4833131 (1989-05-01), Williams et al.
patent: 4840941 (1989-06-01), Ueno et al.
patent: 4876250 (1989-10-01), Clark
patent: 4895838 (1990-01-01), McCluer et al.
patent: 4912093 (1990-03-01), Michaeli
patent: 4921838 (1990-05-01), Catsimpoolas et al.
patent: 4965347 (1990-10-01), Misaki et al.
patent: 4966890 (1990-10-01), Gillespie
patent: 5055301 (1991-10-01), Voigt et al.
Ingber et al., "A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids:Induction of Capillary Basement Membrane Dissolution"; Endocrinology, vol. 119, No. 4, Oct. 1986, pp. 1768-1775.
Taylor et al., "Protamine is an inhibitor of angiogenesis"; Nature, vol. 297, May 27, 1982, pp. 307-312.
Advances in Cancer Research, 43, 175 (1985).
Science, 221, 719 (1983).
Annals of Surgery, 206, 374 (1987).
Laboratory investigation, 59, 44 (1988).
J. Pharmacol. Exp. Ther., 244, 729 (1988).
The Merck Index, 9th edition, 1976, Paragraph 2907, p. 387.
The Merck Index, 11th edition, 1989, Paragraph 2925, pp. 464-465 and Paragraph 4571, p. 735.
Carbohydrate Res., 17, 109 (1971).
J. Biol. Chem., 239, 2986 (1964).
J. Antibiotics, 34, 1355 (1981).
Biochem. Pharmacology, 31, 915 (1982).
J. Antiobiotics, 40, 1231 (1987).
J. Antiboitcs, 40, 1239 (1987).
J. Am. Chem. Soc., 83, 3096 (1961).
Science, 230, 1375 (1985).
Endocr. 1768-1775 (1986), vol. 119, Ingber, et al.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Angiostatic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Angiostatic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Angiostatic agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-778423

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.