Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-06
1996-10-29
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 9, 500 11, 500 17, 500 28, A61K 3812
Patent
active
055696473
ABSTRACT:
The invention relates to a compound selected from those of formula (I) (SEQ ID NO:1): ##STR1## in which R.sub.1, R.sub.2, X.sub.1 and X.sub.2 are as defined in the description, useful as inhibitor of the proliferation component of vascular smooth muscle cells.
REFERENCES:
patent: 4603120 (1986-07-01), Kamber
patent: 4650787 (1987-03-01), Schally et al.
patent: 5147856 (1992-09-01), Ramwell et al.
patent: 5204326 (1993-04-01), Fujii et al.
Amtorp, Continuous Angiopeptin Infusion Reduces Coronary Restinosis Following Balloon Angioplasty, Eur. Heart Journal 14, 276 (1993).
McCombe, Effect of a Long-Acting Somatostatin Analog (BIM23014) on Proliferative Diabetic Retinopathy: A Pilot Study, Eye 5(5), 569-575 (1991).
Prevost, Molecular Heterogeneity of Somatostatin Analogue BIM-23014C Receptors in Human Breast Carcinoma Cells Using the Chemical Cross-Linking Assay, Cancer Research 52(4), 843-850 (1992).
Cotto, Phase I Study of the Somatostatin Analogue Somatuline in Refractory Small-Cell Lung Carcinoma, Annals of Oncology 5(3), 290-291 (1994).
Yagoda, Cytotoxic Chemotherapy for Advanced Hormone-Resistant Prostate Cancer, Cancer 71(3) Suppl., 1098-1103 (1993).
Venier, Treatment of Severe Psoriasis with Somatostatin: Four Years of Experience, Arch. Dermatol. Res. 280 (Suppl), S51-S54 (1988).
Murphy et al, Life Sciences, vol. 40, pp. 2515-2522, (1987).
Schroder et al, The Peptides, vol. 1, pp. 150-151, (1965).
Fauchere Jean-Luc
Janiak Philip
Thurieau Christophe
Vilaine Jean-Paul
Adir et Compagnie
Schain Howard E.
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