Angiographic method using green porphyrins in primate eyes

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514410, 514912, A61K 3140, A61K 4742

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active

057079862

ABSTRACT:
An angiographic method to observe the condition of blood vessels, including neovasculature in the eyes of living primates using green porphyrins and light at a wavelength of 550-700 nm to effect fluorescence is disclosed.

REFERENCES:
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patent: 5214036 (1993-05-01), Allison et al.
Schmidt et al., "Photosensitizing Potency of Benzoporphyrin Derivative (BPD) Associated with Human Low Density Lipoprotein (LDL)", IOVS(1992) 33:1253 Abstract 2802.
Lin et al., "Measurement of BPD Photosensitizer Kinetics in Retinal and Choroidal Vessels by Fluorescence Imaging", IOVS (1933) 34:1168 Abstract 2293.
Lin et al., "Photodynamic Closure of Choroidal Vessels Using Benzoporphyrin Derivative", IOVS (1993) 34:1303 Abstract 2953.
Schmidt-Erfurth et al., "Photothrombosis of Ocular Neovascularization Using Benzoporphyrin (BPD)", IOVS (1993) 34:1303 Abstracts 2956.
Haimovici et al., "Localization of Benzoporphyrin Derivative Monoacid in the Rabbit Eye", IOVS (1993) 34:1303 Abstracts 2955.
Walsh et al., "Photodynamic Therapy of Experimental Choroidal Neovascularization Using Benzoporphyrin Derivative Monoacid", IOVS (1993) 34:1303 Abstracts 2954.
Moulton et al., "Response of Retinal and Choroidal Vessels to Photodynamic Therapy Using Benzoporphyrin Derivative Monoacid", IOVS (1993) 34:1169 Abstract 58.
Gonzales et al., "Photodynamic Therapy of Pigmented Choroidal Melanomas", IOVS (1993) 34:891 Abstract 949.
Schmidt-Erfurth et al., "Photodynamic Therapy of Experimental Choroidal Melanoma Using Lipoprotein-delivered Benzoporphyrin", Ophthalmology (1994) 101:89-99.
Pandey et al., "Efficient Synthesis of New Classes of Regiochemically Pure Benzoporphyrin Derivatives", Bioorganic & Medicinal Chemistry Letters (3)12:2615-2618 (1993).

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